Moderate and high disease activity levels increase the risk of subclinical atherosclerosis progression in early rheumatoid arthritis: a 5-year prospective study

被引:1
|
作者
Meng, Huan [1 ]
Cheng, Isaac T. [1 ]
Yan, Bryan Ping Yen [1 ]
Lee, Alex P. [1 ]
So, Ho [1 ]
Tam, Lai-Shan [1 ]
机构
[1] Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Peoples R China
来源
RMD OPEN | 2024年 / 10卷 / 01期
关键词
Atherosclerosis; Inflammation; Arthritis; Rheumatoid; Therapeutics; INTIMA-MEDIA THICKNESS; CARDIOVASCULAR EVENTS; AMERICAN-COLLEGE; CAROTID ATHEROSCLEROSIS; PSORIATIC-ARTHRITIS; INFLAMMATION; RECOMMENDATIONS; BLOCKADE; BURDEN; DRUGS;
D O I
10.1136/rmdopen-2023-003488
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives To elucidate the association between different disease activity levels over time on long-term vascular outcomes in patients with early rheumatoid arthritis (ERA). Methods This was a 5-year prospective study. Patients with consecutive ERA without overt cardiovascular disease (CVD) were recruited to receive 1 year of tight-control treatment followed by standard-of-care management. High-resolution carotid ultrasound was assessed at baseline and year 5. The primary outcome was subclinical atherosclerosis progression (AP+), defined as the occurrence of incident plaque, increased region harbouring plaques and/or maximum carotid intima-media thickness progression >= 0.9 mm at year 5. Inflammatory burden during the follow-up period was represented by the cumulative average Disease Activity Score 28-erythrocyte sedimentation rate (ca-DAS28-ESR). Persistent low disease activity (LDA) or remission state was defined as ca-DAS28-ESR <= 3.2. Results One-hundred and four patients with ERA (age: 52 +/- 11 years, 81 (77.9%) female) were included in this analysis. Fifty-two (50%) patients achieved persistent LDA or remission and 42 patients (40.4%) had AP+. Patients in the AP+ group were older and had more traditional cardiovascular risk factors at baseline. Multivariate logistic regression analysis revealed that patients with persistent moderate or high disease activity (ca-DAS28-ESR>3.2) had a significantly increased risk of AP+ (OR 5.05, 95% CI 1.53, 16.64, p=0.008) compared with those who achieved persistent remission. The risk of AP+ was similar in patients who achieved persistent LDA and remission. Conclusions Achieving persistent LDA or remission may prevent progression of atherosclerosis in ERA. A treat-to-target approach aiming at sustained LDA or remission may reduce the risk of CVD by preventing AP+. No data are available.
引用
收藏
页数:10
相关论文
共 47 条
  • [1] Effect of Achieving Minimal Disease Activity on the Progression of Subclinical Atherosclerosis and Arterial Stiffness: A Prospective Cohort Study in Psoriatic Arthritis
    Cheng, Isaac T.
    Shang, Qing
    Li, Edmund K.
    Wong, Priscilla C.
    Kun, Emily W.
    Law, Mei Yan
    Yip, Ronald M.
    Yim, Isaac C.
    Lai, Billy T.
    Ying, Shirley K.
    Kwok, Kitty Y.
    Li, Martin
    Li, Tena K.
    Zhu, Tracy Y.
    Lee, Jack J.
    Chang, Mimi M.
    Szeto, Cheuk-Chun
    Yan, Bryan P.
    Lee, Alex P.
    Tam, Lai-Shan
    ARTHRITIS & RHEUMATOLOGY, 2019, 71 (02) : 271 - 280
  • [2] The Extent of Subclinical Atherosclerosis Is Partially Predicted by the Inflammatory Load: A Prospective Study over 5 Years in Patients with Rheumatoid Arthritis and Matched Controls
    Sodergren, Anna
    Karp, Kjell
    Bengtsson, Christine
    Moller, Bozena
    Rantapaa-Dahlqvist, Solbritt
    Wallberg-Jonsson, Solveig
    JOURNAL OF RHEUMATOLOGY, 2015, 42 (06) : 935 - 942
  • [3] Traditional cardiovascular risk factors and residual disease activity are associated with atherosclerosis progression in rheumatoid arthritis patients
    Dalbeni, Andrea
    Giollo, Alessandro
    Bevilacqua, Michele
    Cioffi, Giovanni
    Tagetti, Angela
    Cattazzo, Filippo
    Orsolini, Giovanni
    Ognibeni, Federica
    Minuz, Pietro
    Rossini, Maurizio
    Fava, Cristiano
    Viapiana, Ombretta
    HYPERTENSION RESEARCH, 2020, 43 (09) : 922 - 928
  • [4] Increased Cardiovascular Events and Subclinical Atherosclerosis in Rheumatoid Arthritis Patients: 1 Year Prospective Single Centre Study
    Ruscitti, Piero
    Cipriani, Paola
    Masedu, Francesco
    Romano, Silvio
    Berardicurti, Onorina
    Liakouli, Vasiliki
    Carubbi, Francesco
    Di Benedetto, Paola
    Alvaro, Saverio
    Penco, Maria
    Valenti, Marco
    Giacomelli, Roberto
    PLOS ONE, 2017, 12 (01):
  • [5] Hypoadiponectinemia As an Independent Predictor for the Progression of Carotid Atherosclerosis: A 5-Year Prospective Study
    Hui, Elaine
    Xu, Aimin
    Chow, Wing-Sun
    Lee, Paul C. H.
    Fong, Carol H. Y.
    Cheung, Stephen C. W.
    Tse, Hung Fat
    Chau, Ming-Tak
    Cheung, Bernard M. Y.
    Lam, Karen S. L.
    METABOLIC SYNDROME AND RELATED DISORDERS, 2014, 12 (10) : 517 - 522
  • [6] Serum irisin level in rheumatoid arthritis patients: Relationship to disease activity, subclinical atherosclerosis, and cardiovascular risk factors
    Soliman, Samar A.
    Gad, Reem
    Senosy, Tarek
    Higazi, Aliaa M.
    Elshereef, Rawhya
    EGYPTIAN RHEUMATOLOGIST, 2022, 44 (02): : 109 - 114
  • [7] Subclinical and clinical atherosclerosis in rheumatoid arthritis: results from the 3-year, multicentre, prospective, observational GIRRCS (Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale) study
    Ruscitti, Piero
    Cipriani, Paola
    Liakouli, Vasiliki
    Iacono, Daniela
    Pantano, Ilenia
    Margiotta, Domenico Paolo Emanuele
    Navarini, Luca
    Castaniti, Giulia Maria Destro
    Maruotti, Nicola
    Di Scala, Gerardo
    Picciariello, Licia
    Caso, Francesco
    Bongiovanni, Sara
    Grembiale, Rosa Daniela
    Atzeni, Fabiola
    Scarpa, Raffaele
    Perosa, Federico
    Emmi, Giacomo
    Cantatore, Francesco Paolo
    Guggino, Giuliana
    Afeltra, Antonella
    Ciccia, Francesco
    Giacomelli, Roberto
    ARTHRITIS RESEARCH & THERAPY, 2019, 21 (01)
  • [8] Progression of subclinical atherosclerosis in systemic lupus erythematosus versus rheumatoid arthritis: the impact of low disease activity
    Kravvariti, Evrydiki
    Konstantonis, George
    Sfikakis, Petros P.
    Tektonidou, Maria G.
    RHEUMATOLOGY, 2018, 57 (12) : 2158 - 2166
  • [9] Cardiovascular disease risk calculators to reflect the subclinical atherosclerosis of coronary artery in rheumatoid arthritis: a pilot study
    Kim, Se Hee
    Lee, Sang-Heon
    Kim, Hae-Rim
    Min, Hong Ki
    BMC RHEUMATOLOGY, 2021, 5 (01)
  • [10] Plasma pentraxin 3 is associated with progression of radiographic joint damage, but not carotid atherosclerosis, in female rheumatoid arthritis patients: 3-year prospective study
    Asanuma, Yu Funakubo
    Aizaki, Yoshimi
    Noma, Hisashi
    Yokota, Kazuhiro
    Matsuda, Mayumi
    Kozu, Noritsune
    Takebayashi, Yoshitake
    Nakatani, Hiroshi
    Hasunuma, Tomoko
    Kawai, Shinichi
    Mimura, Toshihide
    MODERN RHEUMATOLOGY, 2020, 30 (06) : 959 - 966