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Univ Bristol, Sch Med Sci, Dept Pathol & Microbiol, Canc Res UK Colorectal Tumour Biol Res Grp, Bristol BS8 1TD, Avon, England Univ Bristol, Sch Med Sci, Dept Pathol & Microbiol, Canc Res UK Colorectal Tumour Biol Res Grp, Bristol BS8 1TD, Avon, England