Efficacy and tolerability of monoamine oxidase inhibitors for the treatment of depressive episodes in mood disorders: A systematic review and network meta-analysis

被引:2
|
作者
Gimenez-Palomo, Anna [1 ,2 ,3 ,4 ]
Chamdal, Anjli K. [5 ,6 ]
Gottlieb, Natalie [5 ]
Lotfaliany, Mojtaba [7 ,8 ]
Jokinen, Tahir [5 ]
Bastawy, Eslam M. [7 ,8 ,9 ]
Adlington, Katherine [5 ]
Benachar, Nawal [10 ,11 ]
Dodd, Seetal [7 ,8 ,12 ,13 ]
Pacchiarotti, Isabella [1 ,2 ,3 ,4 ,14 ]
Vieta, Eduard [1 ,2 ,3 ,4 ,14 ]
Berk, Michael [7 ,8 ,12 ,13 ,15 ]
Stokes, Paul R. A. [5 ]
机构
[1] Univ Barcelona UB, Dept Med, Fac Med & Ciencies Salut, C Casanova143, Barcelona 08036, Spain
[2] Hosp Clin Barcelona, Bipolar & Depress Disorders Unit, Barcelona, Spain
[3] Inst Invest Biomed August Pi i Sunyer IDIBAPS, Barcelona, Spain
[4] Inst Neurosci UBNeuro, Barcelona, Spain
[5] Kings Coll London, Ctr Affect Disorders, Dept Psychol Med, Inst Psychiat Psychol & Neurosci, London, England
[6] East Kent Hosp Univ NHS Fdn Trust, Kent, England
[7] Deakin Univ, IMPACT Inst Mental & Phys Hlth & Clin Translat, Sch Med, Geelong, Vic, Australia
[8] Barwon Hlth, Geelong, Vic, Australia
[9] Ain Shams Univ, Fac Sci, Cairo, Egypt
[10] East & North Hertfordshire NHS Trust, Dept Psychiat, Stevenage, Herts, England
[11] Univ Oxford, Wolfson Coll, Fac Med Educ, Oxford, England
[12] Univ Melbourne, Dept Psychiat, Parkville, Vic, Australia
[13] Univ Melbourne, Ctr Youth Mental Hlth, Parkville, Vic, Australia
[14] Inst Salud Carlos III, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
[15] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Parkville, Australia
基金
澳大利亚国家健康与医学研究理事会;
关键词
antidepressants; depression; monoamine oxidase inhibitors; mood disorders; treatment; TREATMENT-RESISTANT DEPRESSION; TRANYLCYPROMINE; ANTIDEPRESSANTS; GUIDELINES; MOCLOBEMIDE;
D O I
10.1111/acps.13728
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
BackgroundMonoamine oxidase inhibitors (MAOIs) are considered third-line treatments for treatment resistant depression; however, they are underused in clinical practice.AimsThis study aimed to assess the efficacy, tolerability, and acceptability of MAOIs for the treatment of depression in comparison with other antidepressant treatments.MethodsA systematic review and network meta-analysis of randomised clinical trials was performed to compare the efficacy, tolerability and acceptability between MAOIs and other antidepressant treatments for the treatment of depressive episodes.ResultsA total of 83 double-blinded, randomised controlled trials were included in the analysis, with 7765 participants assigned to an active treatment and 1844 assigned to placebo. Several MAOIs, including isocarboxazid, phenelzine, tranylcypromine and moclobemide, showed significantly higher efficacy compared with placebo. The tolerability and acceptability of MAOIs was comparable to other antidepressants.LimitationsA disproportionate number of studies investigating the most commonly used MAOIs, such as moclobemide and phenelzine, and a lack of specific studies focusing on treatment-resistant and atypical depression.ConclusionsMAOIs are similar in efficacy to other antidepressants for the treatment of depression. However, more studies are needed comparing MAOI treatment in people with treatment-resistant, atypical and bipolar depression.
引用
收藏
页码:500 / 515
页数:16
相关论文
共 50 条
  • [21] Efficacy and safety/tolerability of antipsychotics in the treatment of adult patients with major depressive disorder: a systematic review and meta-analysis
    Kishimoto, Taishiro
    Hagi, Katsuhiko
    Kurokawa, Shunya
    Kane, John M.
    Correll, Christoph U.
    PSYCHOLOGICAL MEDICINE, 2023, 53 (09) : 4064 - 4082
  • [22] Efficacy and safety of electroconvulsive therapy in depressive disorders: a systematic review and meta-analysis
    Carney, S
    Cowen, P
    Geddes, J
    Goodwin, G
    Rogers, R
    Dearness, K
    Tomlin, A
    Eastaugh, J
    Freemantle, N
    Lester, H
    Harvey, A
    Scott, A
    LANCET, 2003, 361 (9360): : 799 - 808
  • [23] Repetitive Transcranial Magnetic Stimulation for the Acute Treatment of Major Depressive Episodes A Systematic Review With Network Meta-analysis
    Brunoni, Andre R.
    Chaimani, Anna
    Moffa, Adriano H.
    Razza, Lais B.
    Gattaz, Wagner F.
    Daskalakis, Zafiris J.
    Carvalho, Andre F.
    JAMA PSYCHIATRY, 2017, 74 (02) : 143 - 152
  • [24] Efficacy and safety/tolerability of atypical antipsychotics in the treatment of bipolar depression: a systematic review and network meta-analysis
    Hagi, K.
    Nosaka, T.
    Pikalov, A.
    Loebel, A.
    Correll, C.
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2019, 29 : S87 - S88
  • [25] The efficacy of light therapy in the treatment of mood disorders: A review and meta-analysis of the evidence
    Golden, RN
    Gaynes, BN
    Ekstrom, RD
    Hamer, RM
    Jacobsen, FM
    Suppes, T
    Wisner, KL
    Nemeroff, CB
    AMERICAN JOURNAL OF PSYCHIATRY, 2005, 162 (04): : 656 - 662
  • [26] Efficacy and Tolerability of Benzodiazepines versus Antidepressants in Anxiety Disorders: A Systematic Review and Meta-Analysis
    Offidani, Emanuela
    Guidi, Jenny
    Tomba, Elena
    Fava, Giovanni Andrea
    PSYCHOTHERAPY AND PSYCHOSOMATICS, 2013, 82 (06) : 355 - 362
  • [27] Comparative efficacy and tolerability of different anesthetics in electroconvulsive therapy for major depressive disorder: A systematic review and network meta-analysis
    Ren, Li
    Yu, Jian
    Zeng, Jie
    Wei, Ke
    Li, Ping
    Luo, Jie
    Shen, Yiwei
    Lv, Feng
    Min, Su
    JOURNAL OF PSYCHIATRIC RESEARCH, 2024, 171 : 116 - 125
  • [28] Pharmacological Treatment of Mood Disorders and Comorbid Addictions: A Systematic Review and Meta-Analysis
    Stokes, Paul R. A.
    Jokinen, Tahir
    Amawi, Sami
    Qureshi, Mutahira
    Husain, Muhammad Ishrat
    Yatham, Lakshmi N.
    Strang, John
    Young, Allan H.
    CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE, 2020, 65 (11): : 749 - 769
  • [29] The efficacy and tolerability of inhaled nitrous oxide in major depressive disorder: a systematic review and meta-analysis
    Youjia Qiu
    Longyuan Li
    Aojie Duan
    Menghan Wang
    Minjia Xie
    Zhouqing Chen
    Zhong Wang
    Psychopharmacology, 2023, 240 : 2033 - 2043
  • [30] The efficacy and tolerability of inhaled nitrous oxide in major depressive disorder: a systematic review and meta-analysis
    Qiu, Youjia
    Li, Longyuan
    Duan, Aojie
    Wang, Menghan
    Xie, Minjia
    Chen, Zhouqing
    Wang, Zhong
    PSYCHOPHARMACOLOGY, 2023, 240 (10) : 2033 - 2043