DNA-Based Molecular Machines: Controlling Mechanisms and Biosensing Applications

被引：1

作者：

Ma, Chunran ^{[1
]}

Li, Shiquan ^{[1
]}

Zeng, Yuqi ^{[1
]}

Lyu, Yifan ^{[1
,2
]}

机构：

[1] Hunan Univ, Coll Chem & Chem Engn, Aptamer Engn Ctr Hunan Prov, Mol Sci & Biomed Lab MBL,State Key Lab Chemo Biose, Changsha 410082, Peoples R China

[2] Furong Lab, Changsha 410082, Peoples R China

来源：

BIOSENSORS-BASEL | 2024年 / 14卷 / 05期

关键词：

molecular machines; DNA nanotechnology; controlling mechanism; biosensing; multiplex detection; real-time monitoring; ANTIGEN-DETECTION; PH CHANGES; WALKING; WALKER; DRIVEN; MOTOR; NANOMACHINE; ACTIVATION; TRANSPORT; TWEEZERS;

D O I：

10.3390/bios14050236

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The rise of DNA nanotechnology has driven the development of DNA-based molecular machines, which are capable of performing specific operations and tasks at the nanoscale. Benefitting from the programmability of DNA molecules and the predictability of DNA hybridization and strand displacement, DNA-based molecular machines can be designed with various structures and dynamic behaviors and have been implemented for wide applications in the field of biosensing due to their unique advantages. This review summarizes the reported controlling mechanisms of DNA-based molecular machines and introduces biosensing applications of DNA-based molecular machines in amplified detection, multiplex detection, real-time monitoring, spatial recognition detection, and single-molecule detection of biomarkers. The challenges and future directions of DNA-based molecular machines in biosensing are also discussed.

引用

页数：24

共 145 条

[1] Cooperative cargo transportation by a swarm of molecular machines [J].

Akter, M. ;

Keya, J. J. ;

Kayano, K. ;

Kabir, A. M. R. ;

Inoue, D. ;

Hess, H. ;

Sada, K. ;

Kuzuya, A. ;

Asanuma, H. ;

Kakugo, A. .

SCIENCE ROBOTICS, 2022, 7 (65)

[2] Active Mechanical Threading by a Molecular Motor [J].

Bach, Nicolai N. ;

Josef, Verena ;

Maid, Harald ;

Dube, Henry .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 61 (19)

[3] A molecular elevator [J].

Badjic, JD ;

Balzani, V ;

Credi, A ;

Silvi, S ;

Stoddart, JF .

SCIENCE, 2004, 303 (5665) :1845-1849

[4] Operating molecular elevators [J].

Badjic, JD ;

Ronconi, CM ;

Stoddart, JF ;

Balzani, V ;

Silvi, S ;

Credi, A .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (05) :1489-1499

[5] A synthetic icosahedral DNA-based host-cargo complex for functional in vivo imaging [J].

Bhatia, Dhiraj ;

Surana, Sunaina ;

Chakraborty, Saikat ;

Koushika, Sandhya P. ;

Krishnan, Yamuna .

NATURE COMMUNICATIONS, 2011, 2

[6] Highly Polyvalent DNA Motors Generate 100+pN of Force via Autochemophoresis [J].

Blanchard, Aaron T. ;

Bazrafshan, Alisina S. ;

Yi, Jacob ;

Eisman, Julia T. ;

Yehl, Kevin M. ;

Bian, Teng ;

Mugler, Andrew ;

Salaita, Khalid .

NANO LETTERS, 2019, 19 (10) :6977-6986

[7] All-Photochemical Rotation of Molecular Motors with a Phosphorus Stereoelement [J].

Boursalian, Gregory B. ;

Nijboer, Eise R. ;

Dorel, Ruth ;

Pfeifer, Lukas ;

Markovitch, Omer ;

Blokhuis, Alex ;

Feringa, Ben L. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2020, 142 (39) :16868-16876

[8] Self-Assembled DNA Nanoflowers Triggered by a DNA Walker for Highly Sensitive Electrochemical Detection of Staphylococcus aureus [J].

Cai, Rongfeng ;

Zhang, Shixin ;

Chen, Luo ;

Li, Maolin ;

Zhang, Yuting ;

Zhou, Nandi .

ACS APPLIED MATERIALS & INTERFACES, 2021, 13 (04) :4905-4914

[9] Multitarget Reaction Programmable Automatic Diagnosis and Treatment Logic Device [J].

Cai, Zhiheng ;

Fu, Yingqiang ;

Qiu, Zhili ;

Wang, Ying ;

Wang, Wandong ;

Gu, Wenxiang ;

Li, Zheng ;

Wu, Shengyue ;

Gao, Fenglei .

ACS NANO, 2021, 15 (12) :19150-19164

[10] DNA computational device-based smart biosensors [J].

Cao, Mengyao ;

Xiong, Xiewei ;

Zhu, Yun ;

Xiao, Mingshu ;

Li, Li ;

Pei, Hao .

TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2023, 159

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