Immunomethylomic profiles of long-term head and neck squamous cell carcinoma survivors on immune checkpoint inhibitors

被引：2

作者：

Lee, Min Kyung ^{[1
]}

Zhang, Ze ^{[1
]}

Sehgal, Kartik ^{[2
]}

Butler, Rondi ^{[3
,4
]}

Stolrow, Hannah ^{[1
]}

Ramush, Geat ^{[3
,4
]}

Shirai, Keisuke ^{[5
]}

Koestler, Devin C. ^{[6
]}

Salas, Lucas A. ^{[1
]}

Wiencke, John K. ^{[7
]}

Haddad, Robert ^{[2
]}

Kelsey, Karl T. ^{[3
,4
]}

Christensen, Brock C. ^{[1
,8
,9
]}

机构：

[1] Geisel Sch Med Dartmouth, Dept Epidemiol, Lebanon, NH 03755 USA

[2] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02215 USA

[3] Brown Univ, Dept Epidemiol, Sch Publ Hlth, Providence, RI 02903 USA

[4] Brown Univ, Dept Pathol & Lab Med, Sch Med, Providence, RI 02903 USA

[5] Dartmouth Hitchcock Med Ctr, Dept Med, Lebanon, NH 03766 USA

[6] Univ Kansas, Med Ctr, Dept Biostat & Data Sci, Kansas City, KS 66103 USA

[7] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA 94143 USA

[8] Geisel Sch Med Dartmouth, Dept Mol & Syst Biol, Lebanon, NH 03755 USA

[9] Geisel Sch Med Dartmouth, Dept Community & Family Med, Lebanon, NH 03755 USA

来源：

EPIGENOMICS | 2024年 / 16卷 / 11-12期

基金：

美国国家卫生研究院;

关键词：

DNA methylation; head and neck squamous cell carcinoma; immune checkpoint inhibitors; immune profiles; immunomethylomics; methylation cytometry; MEMORY T-CELLS; DNA METHYLATION;

D O I：

10.1080/17501911.2024.2343274

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Aim: This study addresses the challenge of predicting the response of head and neck squamous cell carcinoma (HNSCC) patients to immunotherapy. Methods: Using DNA methylation cytometry, we analyzed the immune profiles of six HNSCC patients who showed a positive response to immunotherapy over a year without disease progression. Results: There was an initial increase in CD8 T memory cells and natural killer cells during the first four cycles of immunotherapy, which then returned to baseline levels after a year. Baseline CD8 T cell levels were lower in HNSCC immunotherapy responders but became similar to those in healthy subjects after immunotherapy. Conclusion: These findings suggest that monitoring fluctuations in immune profiles could potentially identify biomarkers for immunotherapy response in HNSCC patients.

引用

页码：799 / 807

页数：9

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