An unusual cause of significantly elevated blood alpha-fetoprotein levels: a case report and literature review

被引：0
|
作者：
Zheng, Yue [1 ]
Yao, Jianping [2 ]
Liu, Jin [3 ]
Zhao, Feimin [1 ]
机构：
[1] Zhejiang Chinese Med Univ, Affiliated Cent Hosp Huzhou Univ, Huzhou Cent Hosp, Dept Gen Med,Sch Clin Med 5, Huzhou, Zhejiang, Peoples R China
[2] Zhejiang Chinese Med Univ, Affiliated Cent Hosp Huzhou Univ, Huzhou Cent Hosp, Dept Endocrinol,Sch Clin Med 5, Huzhou, Zhejiang, Peoples R China
[3] Zhejiang Chinese Med Univ, Affiliated Cent Hosp Huzhou Univ, Huzhou Cent Hosp, Dept Pathol,Sch Clin Med 5, Huzhou, Zhejiang, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2024年 / 14卷
关键词：
alpha-fetoprotein; gastric cancer; gastric hepatoid adenocarcinoma; metastasis; clinical application; GASTRIC-CANCER; HEPATOID ADENOCARCINOMA; AFP; PROGNOSIS; STOMACH;
D O I：
10.3389/fonc.2024.1393074
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Alpha-fetoprotein (AFP) serves as a crucial diagnostic marker for primary hepatocellular carcinoma (HCC) and germ cell tumors (GCTs), with rare instances of significantly elevated levels in other diseases. In this study, we present a case of an elderly patient who was diagnosed with AFP-producing gastric cancer (AFPGC) following an elevated AFP result during physical examination. In investigating liver cancer at an early stage, the diagnosis was missed because of failure in detecting the lesion, resulting in delayed treatment initiation. AFPGC is a rare aggressive tumor that demands heightened awareness among clinicians to foster early detection, diagnosis, and treatment for improved prognosis.
引用
收藏
页数：5
相关论文
共 50 条
  • [41] OVARIAN MUCINOUS CYSTADENOCARCINOMA PRODUCING ALPHA-FETOPROTEIN - A CASE-REPORT
    NOMURA, K
    MIYASAKA, Y
    MURAE, M
    TERASHIMA, Y
    AIZAWA, S
    ACTA PATHOLOGICA JAPONICA, 1992, 42 (05): : 372 - 375
  • [42] Alpha-fetoprotein level in fetuses, infants, and children with ovarian masses: a literature review
    Matonog, Aleksandra
    Drosdzol-Cop, Agnieszka
    FRONTIERS IN ENDOCRINOLOGY, 2024, 15
  • [43] Vimentin-positive and Alpha-fetoprotein-elevated Nuclear Protein of the Testis Midline Carcinoma: A Case Report and Review of the Literature
    Murano, Chihiro
    Suzuki, Shuhei
    Nakamura, Sho
    Takeda, Hiroyuki
    Fukui, Tadahisa
    Yoshioka, Takashi
    INTERNAL MEDICINE, 2021, 60 (22) : 3645 - 3649
  • [44] A Case of a Testicular Tumor Histologically Described as a Seminoma in a Patient With an Elevated Serum Alpha-Fetoprotein
    Burton, Kyle A.
    Acharya, Sheetal
    Pahn, Brian
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2023, 15 (06)
  • [45] Persistently elevated alpha-fetoprotein associated with chronic hepatitis B during chemotherapy for malignant ovarian germ cell tumors: a case series and a review of the literature
    Xuan Zong
    Jia-Xin Yang
    Ying Zhang
    Journal of Ovarian Research, 12
  • [46] Elevated Serum Levels of Alpha-Fetoprotein in Patients with Infantile Hemangioma Are Not Derived from within the Tumor
    Itinteang, Tinte
    Chibnall, Alice M.
    Marsh, Reginald
    Dunne, Jonathan C.
    de Jong, Sophie
    Davis, Paul F.
    Leadbitter, Philip
    Tan, Swee T.
    FRONTIERS IN SURGERY, 2016, 3
  • [47] Rapid Response to the Combination of Lenvatinib and Sintilimab in a Pancreatic Acinar Cell Carcinoma Patient With Elevated Alpha-Fetoprotein: A Case Report
    Qin, Lanqun
    Shen, Jie
    Yang, Yueling
    Zou, Zhengyun
    FRONTIERS IN ONCOLOGY, 2021, 11
  • [48] α-fetoprotein-producing gastric carcinoma: A case report of a rare subtype and literature review
    Sun, Ningbo
    Sun, Qing
    Liu, Qun
    Zhang, Tianxiao
    Zhu, Qiang
    Wang, Wei
    Cao, Ming
    Zang, Qi
    ONCOLOGY LETTERS, 2016, 11 (05) : 3101 - 3104
  • [49] Persistent increase in alpha-fetoprotein level in a patient without underlying liver disease who underwent curative resection of hepatocellular carcinoma. A case report and review of the literature
    Di Carlo, Isidoro
    Mannino, Maurizio
    Toro, Adriana
    Ardiri, Annalisa
    Galia, Antonio
    Cappello, Giovanni
    Bertino, Gaetano
    WORLD JOURNAL OF SURGICAL ONCOLOGY, 2012, 10
  • [50] Hereditary persistence of α-fetoprotein -: Case report and review of the literature
    Schefer, H
    Mattmann, S
    Joss, RA
    ANNALS OF ONCOLOGY, 1998, 9 (06) : 667 - 672
12345