Does Improving Depression Symptoms in Young Adults With Inflammatory Bowel Disease Alter Their Microbiome?

被引:0
作者
Davies, Julie M. [1 ]
Teh, Jing Jie [2 ]
Ewais, Tatjana [3 ,4 ,5 ]
Begun, Jakob [1 ,6 ]
机构
[1] Univ Queensland, Mater Res, 37 Kent St, Woolloongabba, Qld, Australia
[2] Univ Queensland, Frazer Inst, Woolloongabba, Qld, Australia
[3] Mater Adolescent & Young Adult Hlth Clin, South Brisbane, Qld, Australia
[4] Univ Queensland, Sch Med, St Lucia, Qld, Australia
[5] Griffith Univ, Sch Med & Dent, Gold Coast Campus, Southport, Qld, Australia
[6] Mater Hosp Brisbane, Dept Gastroenterol, South Brisbane, Australia
关键词
microbiome; inflammatory bowel disease; depression; anxiety; adolescents and young adults (AYA); GUT MICROBIOTA; ANXIETY; ASSOCIATION; PREVALENCE; RECURRENCE; DRUGS;
D O I
10.1093/ibd/izae121
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background Patients with inflammatory bowel diseases (IBDs) are more likely to have depression and anxiety symptoms compared with healthy individuals and those with other chronic illnesses. Previous studies have shown a link between the microbiome composition and depression symptoms; however, many antidepressant medications have antibacterial activity confounding cross-sectional studies of these populations. Therefore, we aimed to determine whether we could detect longitudinal changes in the microbiome of a subset of patients who participated in a previously published mindfulness-based cognitive therapy (MBCT) study to improve depression symptoms in adolescents and young adults with IBD.Methods Stool samples were collected at baseline and 8 weeks (n = 24 participants, 37 total samples, 13 paired samples). During this time, some participants achieved a 50% reduction in their depression symptoms either through MBCT or treatment as usual with their mental health team (responders). The microbiome composition and function of responders were compared with participants who did not improve their depression scores (nonresponders). Depression scores were determined using the depression, anxiety, and stress score (DASS-21), and metagenomic sequencing of stool samples was performed.Results No difference in alpha diversity was found between responders and nonresponders. Beta diversity measures were similarly unchanged. Clinical features including fecal calprotectin, C-reactive protein, and serum IL-6 levels were unchanged.Conclusions In this small longitudinal study, we were not able to detect longitudinal changes in the microbiome associated with improvement in depression scores. Follow-up studies that are sufficiently powered to detect changes in the microbiome are required to confirm our results. In a small cohort of young adults with inflammatory bowel disease and depression symptoms, we observed no significant longitudinal changes in their microbiome following improvement in their depression scores.
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收藏
页码:2428 / 2439
页数:12
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共 64 条
[41]   Multivariable association discovery in population-scale meta-omics studies [J].
Mallick, Himel ;
Rahnavard, Ali ;
McIver, Lauren J. ;
Ma, Siyuan ;
Zhang, Yancong ;
Nguyen, Long H. ;
Tickle, Timothy L. ;
Weingart, George ;
Ren, Boyu ;
Schwager, Emma H. ;
Chatterjee, Suvo ;
Thompson, Kelsey N. ;
Wilkinson, Jeremy E. ;
Subramanian, Ayshwarya ;
Lu, Yiren ;
Waldron, Levi ;
Paulson, Joseph N. ;
Franzosa, Eric A. ;
Bravo, Hector Corrada ;
Huttenhower, Curtis .
PLOS COMPUTATIONAL BIOLOGY, 2021, 17 (11)
[42]   Mindfulness-based cognitive therapy for prevention and time to depressive relapse: Systematic review and network meta-analysis [J].
McCartney, Mark ;
Nevitt, Sarah ;
Lloyd, Annette ;
Hill, Ruaraidh ;
White, Ross ;
Duarte, Rui .
ACTA PSYCHIATRICA SCANDINAVICA, 2021, 143 (01) :6-21
[43]   phyloseq: An R Package for Reproducible Interactive Analysis and Graphics of Microbiome Census Data [J].
McMurdie, Paul J. ;
Holmes, Susan .
PLOS ONE, 2013, 8 (04)
[44]   Symptoms of Depression and Anxiety Are Independently Associated With Clinical Recurrence of Inflammatory Bowel Disease [J].
Mikocka-Walus, Antonina ;
Pittet, Valerie ;
Rossel, Jean-Benoit ;
von Kanel, Roland .
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2016, 14 (06) :829-+
[45]   Controversies Revisited: A Systematic Review of the Comorbidity of Depression and Anxiety with Inflammatory Bowel Diseases [J].
Mikocka-Walus, Antonina ;
Knowles, Simon R. ;
Keefer, Laurie ;
Graff, Lesley .
INFLAMMATORY BOWEL DISEASES, 2016, 22 (03) :752-762
[46]   Antimicrobial activity of psychotropic drugs -: Selective serotonin reuptake inhibitors [J].
Munoz-Bellido, JL ;
Munoz-Criado, S ;
Garcìa-Rodrìguez, JA .
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2000, 14 (03) :177-180
[47]   Gut Microbiota Metabolite Indole Propionic Acid Targets Tryptophan Biosynthesis in Mycobacterium tuberculosis [J].
Negatu, Dereje Abate ;
Yamada, Yoshiyuki ;
Xi, Yu ;
Go, Mei Lin ;
Zimmerman, Matthew ;
Ganapathy, Uday ;
Dartois, Veronique ;
Gengenbacher, Martin ;
Dick, Thomas .
MBIO, 2019, 10 (02)
[48]   A Controlled Study of a Group Mindfulness Intervention for Individuals Living With Inflammatory Bowel Disease [J].
Neilson, Kate ;
Ftanou, Maria ;
Monshat, Kaveh ;
Salzberg, Mike ;
Bell, Sally ;
Kamm, Michael A. ;
Connell, William ;
Knowles, Simon R. ;
Sevar, Katherine ;
Mancuso, Sam G. ;
Castle, David .
INFLAMMATORY BOWEL DISEASES, 2016, 22 (03) :694-701
[49]   Depression and anxiety in patients with Inflammatory Bowel Disease: A systematic review [J].
Neuendorf, Rachel ;
Harding, Aubrey ;
Stello, Noelle ;
Hanes, Douglas ;
Wahbeh, Helane .
JOURNAL OF PSYCHOSOMATIC RESEARCH, 2016, 87 :70-80
[50]   Evaluation of the Microba Community Profiler for Taxonomic Profiling of Metagenomic Datasets From the Human Gut Microbiome [J].
Parks, Donovan H. ;
Rigato, Fabio ;
Vera-Wolf, Patricia ;
Krause, Lutz ;
Hugenholtz, Philip ;
Tyson, Gene W. ;
Wood, David L. A. .
FRONTIERS IN MICROBIOLOGY, 2021, 12