In Silico Study, Protein Kinase Inhibition and Molecular Docking Study of Benzimidazole Derivatives

被引:0
|
作者
Karthick, Kamaraj [1 ]
Abishek, Kamaraj [2 ]
Jemima, Ebenezer Angel [3 ]
机构
[1] Rajalakshmi Inst Technol, Dept Chem, Chennai 600124, Tamil Nadu, India
[2] Sadakathullah Appa Coll, Dept Zool, Tirunelveli, Tamil Nadu, India
[3] Trichy Res Inst Biotechnol Pvt Ltd, Trichy, India
来源
BIOINFORMATICS AND BIOLOGY INSIGHTS | 2024年 / 18卷
关键词
Benzimidazole derivatives; in silico study; protein kinase and molecular docking; ANTICANCER; MORTALITY; AGENTS;
D O I
10.1177/11779322241247635
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Kinase enzymes play an important role in cellular proliferation, and inhibition of their activity is a major goal of cancer therapy. Protein kinase inhibitors as benzimidazole derivatives can be applied for prevention or treatment of cancers through inhibition of cell proliferation. To evaluate their protein kinase inhibitory effects, as well as the in silico study for active benzimidazole derivatives. Benzimidazole derivatives has presented significant therapeutic potential against several disorders and known to have numerous biological activities (such as antibacterial, antiviral and anti-inflammatory). Benzimidazole derivatives have shown significant potential in the reduction of viral load as well as in enhancing immunity. To forecast absorption, distribution, metabolism, excretion and toxicity, simply known as ADMET and the Lipinski rule of five parameters of the examined substances, the admetSAR and Swiss ADME were used. The ADMET predictions revealed that the compounds had good and safe pharmacokinetic features, making them acceptable for further development as therapeutic candidates in clinical trials. This study primarily focused on blocking 2 key targets of kinase proteins (CDK4/CycD1 and Aurora B). 2-Phenylbenzimidazole has shown the greatest inhibitory potential (with a binding energy of -8.2 kcal/mol) against protein kinase inhibitors. This study results would pave the potential lead medication for anticancer therapeutic strategies.
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页数:11
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