Quantitative EEG analysis of brivaracetam in drug-resistant epilepsy: A pharmaco-EEG study

被引：2

作者：

Ricci, Lorenzo ^{[1
,2
,3
,9
]}

Tombini, Mario ^{[1
,2
]}

Savastano, Ersilia ^{[4
]}

Pulitano, Patrizia ^{[5
]}

Piccioli, Marta ^{[6
]}

Forti, Marco ^{[3
,7
]}

Sancetta, Biagio ^{[1
]}

Boscarino, Marilisa ^{[1
,8
]}

Narducci, Flavia ^{[1
]}

Mecarelli, Oriano ^{[5
]}

Ciccozzi, Massimo ^{[3
]}

Di Lazzaro, Vincenzo ^{[1
,2
]}

Assenza, Giovanni ^{[1
,2
]}

机构：

[1] Univ Campus Biomed Roma, Dept Med & Surg, Res Unit Neurol, Neurobiol,Neurophysiol, Rome, Italy

[2] Fdn Policlin Univ Campus Biomed Roma, Via Alvaro del Portillo 200, I-00128 Rome, Italy

[3] Univ Campus Biomed Roma, Med Stat & Mol Epidemiol Unit, Rome, Italy

[4] AORN Santobono Pausilipon, UOC Neurol, Via Mario Fiore 6, I-80129 Naples, Italy

[5] Sapienza Univ Rome, Dept Neurol & Psychiat, Rome, Italy

[6] ASL Roma 1, UOC Neurol, PO San Filippo Neri, Rome, Italy

[7] Sapienza Univ Rome, Dept Stat Sci, Rome, Italy

[8] IRCCS, Milano Inst, Ist Clin Sci Maugeri, Neurorehabil Dept, Milan, Italy

[9] Campus Biomed Univ, Neurol, Via Alvaro Portillo 200, I-00128 Rome, Italy

来源：

CLINICAL NEUROPHYSIOLOGY | 2024年 / 163卷

关键词：

Drug -resistant epilepsy; Functional connectivity; Pharmaco-EEG; Brivaracetam; Quantitative EEG analysis; TEMPORAL-LOBE EPILEPSY; FOCAL EPILEPSY; CONNECTIVITY; OSCILLATIONS;

D O I：

10.1016/j.clinph.2024.04.023

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: Brivaracetam (BRV) is a recent antiseizure medication (ASM) approved as an add-on therapy for people with focal epilepsy. BRV has a good efficacy and safety profile compared to other ASMs. However, its specific effects on resting -state EEG activity and connectivity are unknown. The aim of this study is to evaluate quantitative EEG changes induced by BRV therapy in a population of adult people with drug -resistant epilepsy (PwE) compared to healthy controls (HC). Methods: We performed a longitudinal, retrospective, pharmaco-EEG study on a population of 23 PwE and a group of 25 HC. Clinical outcome was dichotomized into drug -responders (i.e., >50% reduction in seizures' frequency; RES) and non -responders (N-RES) after two years of BRV. EEG parameters were compared between PwE and HC at baseline (pre-BRV) and after three months of BRV therapy (post-BRV). We investigated BRV-related variations in EEG connectivity using the phase locking value (PLV). Results: BRV therapy did not induce modifications in power spectrum density across different frequency bands. PwE presented lower PLV connectivity values compared to HC in all frequency bands. RES exhibited lower theta PLV connectivity compared to HC before initiating BRV and experienced an increase after BRV, eliminating the significant difference from HC. Conclusions: This study shows that BRV does not alter the EEG power spectrum in PwE, supporting its favourable neuropsychiatric side -effect profile, and induces the disappearance of EEG connectivity differences between PwE and HC. Significance: The integration of EEG quantitative analysis in epilepsy can provide insights into the efficacy, mechanism of action, and side effects of ASMs. (c) 2024 International Federation of Clinical Neurophysiology. Published by Elsevier B.V.

引用

页码：152 / 159

页数：8

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