Design, synthesis and biological evaluation of aryl isoxazole incorporated pyrimidin-2-yl)oxazolo[4,5-b]pyridine derivatives as anticancer agents

被引：3

作者：

Shaik, Khasim Saheb ^{[1
]}

Saritha, N. ^{[1
]}

Reddy, G. Nagendra ^{[2
]}

机构：

[1] JNTUA Coll Engn, Dept Chem, Kalikiri, Andhra Pradesh, India

[2] Koneru Lakshmaiah Educ Fdn, Dept Chem, Guntur, Andhra Pradesh, India

来源：

RESULTS IN CHEMISTRY | 2024年 / 9卷

关键词：

Benoxaprofen; Benzoxazole; Acivicin; Isoxazole and anticancer activity; COPPER(I)-CATALYZED SYNTHESIS; CYCLIZATION; ANALOGS; INHIBITORS; DISCOVERY; ALKYNES;

D O I：

10.1016/j.rechem.2024.101628

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new library of Aryl Isoxazole Incorporated Pyrimidin-2-yl)oxazolo[4,5-b]pyridine compounds 11a-j and their structures were characterized by analytical data. Further, the preliminary anticancer activity of the newly prepared compounds 11a-j was examined against four types of human cancer cell lines, breast cancer (MCF-7), lung cancer (A549), colon cancer (Colo-205) and ovarian cancer (A2780) by utilizing the MTT method. Most of the compounds displayed good to moderate activities as compared with the etoposide used as a positive control. Amon, five compounds 11a, 11b, 11h, 11i and 11j exhibited more potent activity than the positive control. Mainly, compound 11h displayed superior anticancer activity.

引用

页数：5

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