Efficacy of topical agents in oral mucositis prevention: Systematic review and network meta-analysis

被引：8

作者：

Coppini, Martina ^{[1
,2
]}

Caponio, Vito Carlo Alberto ^{[3
]}

Mauceri, Rodolfo ^{[1
,4
]}

Bizzoca, Maria Eleonora ^{[3
]}

Laino, Luigi ^{[5
]}

Lorenzo-Pouso, Alejandro I. ^{[6
]}

Russo, Diana ^{[5
]}

Troiano, Giuseppe ^{[3
]}

Silva, Fabio Franca Vieira E. ^{[6
,7
]}

Lo Muzio, Lorenzo ^{[3
]}

Campisi, Giuseppina ^{[4
]}

机构：

[1] Univ Palermo, Dept Precis Med Med Surg & Crit Care, Palermo, Italy

[2] Univ Messina, Dept Biomed & Dent Sci & Morphofunct Imaging, Messina, Italy

[3] Univ Foggia, Dept Clin & Expt Med, Foggia, Italy

[4] Fragil & Continu Care Univ Hosp Palermo, Dept Rehabil, Unit Oral Med & Dent Fragile Patients, Palermo, Italy

[5] Univ Campania Luigi Vanvitelli, Multidisciplinary Dept Med Surg & Odontostomatol, Naples, Italy

[6] Univ Santiago de Compostela, Oral Med Oral Surg & Implantol Unit MedOralRes, Fac Med & Dent, Santiago De Compostela, Spain

[7] Hlth Res Inst Santiago de Compostela FIDIS, ORALRES Grp, Santiago De Compostela, Spain

来源：

ORAL DISEASES | 2024年 / 30卷 / 07期

关键词：

cancer; network meta-analysis; oral mucosa; oral mucositis; prevention; stomatitis; sucralfate; systematic review; therapy; NECK-CANCER PATIENTS; CHEMOTHERAPY AND/OR RADIOTHERAPY; RADIATION-INDUCED MUCOSITIS; LACTOBACILLUS-BREVIS CD2; PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND; POVIDONE-IODINE; RANDOMIZED-TRIAL; MANUKA HONEY; RISK-FACTORS;

D O I：

10.1111/odi.15046

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

BackgroundOral mucositis (OM) is considered one of the most common side effects of patients undergoing cancer therapy. OM prevention plays a crucial role in the effectiveness of cancer treatment and the patient's quality of life. Different preventive treatments have been proposed in clinical trials, however with inconclusive results. Materials and MethodsA systematic review search was conducted in PubMed, Scopus, Web of Science, and Cochrane Database to answer the PICO question: in cancer patients, do specific topical agents compared to standard treatments or placebo reduce the onset and severity of oral mucositis? The risk of bias was assessed, and a network meta-analysis was conducted. ResultsOf 2913 results, 30 randomized clinical trials were considered suitable for inclusion. A total of 2564 patients were analyzed, of which 1284 belonged to the test group and 1280 belonged to the control group. Natural products were the most used, followed mainly by antimicrobial agents, coating agents, and basic oral care measures. Topical sucralfate resulted in the most powerful intervention for the OM prevention (OR=0.04, 95%C.I.=0.01-0.25, p-value=0.001). ConclusionDue to its cytoprotective action, low cost, ease of administration, and safety, sucralfate could become a potential ally to prevent the onset of OM during cancer therapy.

引用

页码：4126 / 4144

页数：19

共 87 条

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