Network analysis of S-nitrosylated synaptic proteins demonstrates unique roles in health and disease

被引:3
作者
Stykel, Morgan G. [1 ]
Ryan, Scott D. [1 ,2 ]
机构
[1] Univ Guelph, Dept Mol & Cellular Biol, Guelph, ON, Canada
[2] Univ Calgary, Hotchkiss Brain Inst, Dept Clin Neurosci, Calgary, AB, Canada
来源
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2024年 / 1871卷 / 05期
基金
加拿大健康研究院; 加拿大自然科学与工程研究理事会;
关键词
Nitric oxide; S-nitrosylation; Metabolism; Reactive nitrogen species; Neurodegeneration; Synapse; NITRIC-OXIDE SYNTHASE; METHYL-D-ASPARTATE; NEURONAL NO SYNTHASE; CELL-DEATH; MITOCHONDRIAL PROCESSES; GLUTAMATE RECEPTORS; LATE-PHASE; GENE; PATHWAY; ACTIVATION;
D O I
10.1016/j.bbamcr.2024.119720
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Nitric oxide can covalently modify cysteine thiols on target proteins to alter that protein's function in a process called S-nitrosylation (SNO). S-nitrosylation of synaptic proteins plays an integral part in neurotransmission. Here we review the function of the SNO-proteome at the synapse and whether clusters of SNO-modification may predict synaptic dysfunction associated with disease. We used a systematic search strategy to concatenate SNOproteomic datasets from normal human or murine brain samples. Identified SNO-modified proteins were then filtered against proteins reported in the Synaptome Database, which provides a detailed and experimentally verified annotation of all known synaptic proteins. Subsequently, we performed an unbiased network analysis of all known SNO-synaptic proteins to identify clusters of SNO proteins commonly involved in biological processes or with known disease associations. The resulting SNO networks were significantly enriched in biological processes related to metabolism, whereas significant gene-disease associations were related to Schizophrenia, Alzheimer's, Parkinson's and Huntington's disease. Guided by an unbiased network analysis, the current review presents a thorough discussion of how clustered changes to the SNO-proteome influence health and disease.
引用
收藏
页数:15
相关论文
共 186 条
  • [1] S-Nitrosylation of ApoE in Alzheimer's Disease
    Abrams, Alexander J.
    Farooq, Amjad
    Wang, Gaofeng
    [J]. BIOCHEMISTRY, 2011, 50 (17) : 3405 - 3407
  • [2] NITRIC-OXIDE SYNTHASES REVEAL A ROLE FOR CALMODULIN IN CONTROLLING ELECTRON-TRANSFER
    ABUSOUD, HM
    STUEHR, DJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (22) : 10769 - 10772
  • [3] Development and Characterization of a New Parkinson's Disease Model Resulting from Impaired Autophagy
    Ahmed, Ishrat
    Liang, Yideng
    Schools, Sabitha
    Dawson, Valina L.
    Dawson, Ted M.
    Savitt, Joseph M.
    [J]. JOURNAL OF NEUROSCIENCE, 2012, 32 (46) : 16503 - 16509
  • [4] DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway
    Aleyasin, Hossein
    Rousseaux, Maxime W. C.
    Marcogliese, Paul C.
    Hewitt, Sarah J.
    Irrcher, Isabella
    Joselin, Alvin P.
    Parsanejad, Mohammad
    Kim, Raymond H.
    Rizzu, Patrizia
    Callaghan, Steve M.
    Slack, Ruth S.
    Mak, Tak W.
    Park, David S.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (07) : 3186 - 3191
  • [5] S-nitrosylation of E3 ubiquitin-protein ligase RNF213 alters non-canonical Wnt/Ca+2 signaling in the P301S mouse model of tauopathy
    Amal, Haitham
    Gong, Guanyu
    Gjoneska, Elizabeta
    Lewis, Sarah M.
    Wishnok, John S.
    Tsai, Li-Huei
    Tannenbaum, Steven R.
    [J]. TRANSLATIONAL PSYCHIATRY, 2019, 9 (1)
  • [6] Shank3mutation in a mouse model of autism leads to changes in the S-nitroso-proteome and affects key proteins involved in vesicle release and synaptic function
    Amal, Haitham
    Barak, Boaz
    Bhat, Vadiraja
    Gong, Guanyu
    Joughin, Brian A.
    Wang, Xin
    Wishnok, John S.
    Feng, Guoping
    Tannenbaum, Steven R.
    [J]. MOLECULAR PSYCHIATRY, 2020, 25 (08) : 1835 - 1848
  • [7] Metabolic Bypass Rescues Aberrant S-nitrosylation-Induced TCA Cycle Inhibition and Synapse Loss in Alzheimer's Disease Human Neurons
    Andreyev, Alexander Y.
    Yang, Hongmei
    Doulias, Paschalis-Thomas
    Dolatabadi, Nima
    Zhang, Xu
    Luevanos, Melissa
    Blanco, Mayra
    Baal, Christine
    Putra, Ivan
    Nakamura, Tomohiro
    Ischiropoulos, Harry
    Tannenbaum, Steven R.
    Lipton, Stuart A.
    [J]. ADVANCED SCIENCE, 2024, 11 (12)
  • [8] Aβ and tau prion-like activities decline with longevity in the Alzheimer's disease human brain
    Aoyagi, Atsushi
    Condello, Carlo
    Stohr, Jan
    Yue, Weizhou
    Rivera, Brianna M.
    Lee, Joanne C.
    Woerman, Amanda L.
    Halliday, Glenda
    van Duinen, Sjoerd
    Ingelsson, Martin
    Lannfelt, Lars
    Graff, Caroline
    Bird, Thomas D.
    Keene, C. Dirk
    Seeley, William W.
    DeGrado, William F.
    Prusiner, Stanley B.
    [J]. SCIENCE TRANSLATIONAL MEDICINE, 2019, 11 (490)
  • [9] Coordination between Calcium/Calmodulin-Dependent Protein Kinase II and Neuronal Nitric Oxide Synthase in Neurons
    Araki, Shoma
    Osuka, Koji
    Takata, Tsuyoshi
    Tsuchiya, Yukihiro
    Watanabe, Yasuo
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (21) : 1 - 17
  • [10] Arancio O., 1996, Cell