Hydroxyurea reduces infections in children with sickle cell anemia in Uganda

被引：3

作者：

Namazzi, Ruth ^{[1
,2
]}

Bond, Caitlin ^{[3
]}

Conroy, Andrea L. ^{[3
]}

Datta, Dibyadyuti ^{[3
]}

Tagoola, Abner ^{[4
]}

Goings, Michael J. ^{[3
]}

Jang, Jeong Hoon ^{[5
,6
]}

Ware, Russell E. ^{[7
]}

Opoka, Robert ^{[2
]}

John, Chandy C. ^{[3
]}

机构：

[1] Makerere Univ, Coll Hlth Sci, Dept Pediat & Child Hlth, Kampala, Uganda

[2] Global Hlth Uganda, Kampala, Uganda

[3] Indiana Univ Sch Med, Ryan White Ctr Pediat Infect Dis & Global Hlth, Dept Pediat, 705 Riley Hosp Dr,RI5900, Indianapolis, IN 46202 USA

[4] Jinja Reg Referral Hosp, Dept Pediat, Jinja, Uganda

[5] Yonsei Univ, Underwood Int Coll, Seoul, South Korea

[6] Yonsei Univ, Dept Appl Stat, Seoul, South Korea

[7] Cincinnati Childrens Hosp, Med Ctr, Dept Pediat, Div Hematol, Cincinnati, OH USA

来源：

BLOOD | 2024年 / 143卷 / 14期

关键词：

TOXOPLASMA-GONDII; MALARIA; DISEASE; TRIAL;

D O I：

10.1182/blood.2023021575

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

After starting hydroxyurea treatment, Ugandan children with sickle cell anemia had 60% fewer severe or invasive infections, including malaria, bacteremia, respiratory tract infections, and gastroenteritis, than before starting hydroxyurea treatment (incidence rate ratio, 0.40 [95% confidence interval, 0.29-0.54]; P < .001). © 2024 American Society of Hematology

引用

页码：1425 / 1428

页数：4

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