Hydroxyurea reduces infections in children with sickle cell anemia in Uganda

被引：3
|
作者：
Namazzi, Ruth [1 ,2 ]
Bond, Caitlin [3 ]
Conroy, Andrea L. [3 ]
Datta, Dibyadyuti [3 ]
Tagoola, Abner [4 ]
Goings, Michael J. [3 ]
Jang, Jeong Hoon [5 ,6 ]
Ware, Russell E. [7 ]
Opoka, Robert [2 ]
John, Chandy C. [3 ]
机构：
[1] Makerere Univ, Coll Hlth Sci, Dept Pediat & Child Hlth, Kampala, Uganda
[2] Global Hlth Uganda, Kampala, Uganda
[3] Indiana Univ Sch Med, Ryan White Ctr Pediat Infect Dis & Global Hlth, Dept Pediat, 705 Riley Hosp Dr,RI5900, Indianapolis, IN 46202 USA
[4] Jinja Reg Referral Hosp, Dept Pediat, Jinja, Uganda
[5] Yonsei Univ, Underwood Int Coll, Seoul, South Korea
[6] Yonsei Univ, Dept Appl Stat, Seoul, South Korea
[7] Cincinnati Childrens Hosp, Med Ctr, Dept Pediat, Div Hematol, Cincinnati, OH USA
来源：
BLOOD | 2024年 / 143卷 / 14期
关键词：
TOXOPLASMA-GONDII; MALARIA; DISEASE; TRIAL;
D O I：
10.1182/blood.2023021575
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
After starting hydroxyurea treatment, Ugandan children with sickle cell anemia had 60% fewer severe or invasive infections, including malaria, bacteremia, respiratory tract infections, and gastroenteritis, than before starting hydroxyurea treatment (incidence rate ratio, 0.40 [95% confidence interval, 0.29-0.54]; P < .001). © 2024 American Society of Hematology
引用
收藏
页码：1425 / 1428
页数：4
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