Diagnostic, monitoring, and prognostic value of combined detection of cerebrospinal fluid heparin-binding protein, interleukin-6, interleukin-10, and procalcitonin for post-neurosurgical intracranial infection

Objective: Intracranial infection is a common complication after neurosurgery and can increase the length of hospital stay, affect patient prognosis, and increase mortality. We aimed to investigate the value of the combined detection of cerebrospinal fluid (CSF) heparin-binding protein (HBP), interleukin-6 (IL -6), interleukin-10 (IL -10), and procalcitonin (PCT) for post-neurosurgical intracranial infection. Methods: This study assessed the diagnostic values of CSF HBP, IL -6, IL -10, PCT levels, and combined assays for post-neurosurgical intracranial infection with the area under the receiver operating characteristic (ROC) curve by retrospectively analysing biomarkers of post-neurosurgical patients. Results: The CSF HBP, IL -6, IL -10, and PCT levels were significantly higher in the infected group than the uninfected group and the control group (P < 0.001). The indicators in the groups with severe intracranial infections were significantly higher than those in the groups with mild intracranial infections (P < 0.001), and the groups with poor prognoses had significantly higher indexes than the groups with good prognoses. According to the ROC curve display, the AUC values of CSF HBP, IL -6, IL -10, and PCT were 0.977 (95 % CI 0.952 -1.000), 0.973 (95 % CI 0.949 -0.998), 0.884 (95 % CI 0.823 -0.946), and 0.819 (95 % CI 0.733 -0.904), respectively. The AUC of the combined test was 0.996 (95 % CI 0.989 -1.000), which was higher than those of the four indicators alone. Conclusion: The combined detection can be an important indicator for the diagnosis and disease monitoring of post-neurosurgical intracranial infection.