Do lead (Pb) content of lipsticks expose a health risk to children? A risk assessment study

被引:0
|
作者
Oztas, Demir Mesut [1 ,2 ]
Ulutas, Onur Kenan [3 ]
Berkkan, Aysel [1 ]
机构
[1] Gazi Univ, Fac Pharm, Dept Analyt Chem, TR-06560 Ankara, Turkiye
[2] Turkey Drug & Med Devices Agcy, TR-06520 Ankara, Turkiye
[3] Gazi Univ, Fac Pharm, Dept Toxicol, TR-06560 Ankara, Turkiye
关键词
cancer risk; children health; computer modelling; lead exposure; risk assessment; safety testing; HEAVY-METALS; COSMETICS; PRODUCTS;
D O I
10.1093/pubmed/fdae070
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background Lead (Pb) content in lipsticks and potential life-long exposure of which might cause severe effects in consumers are an important concern for public. Thus, studies emphasize that lead exposure has no safe levels.Methods From 10 different brands, in total, 25 solid, gloss and creamy lipsticks are deployed from Turkish markets that are also categorized in two different price ranges. In order to evaluate the blood Pb levels in children, the United States Environmental Protection Agency's 'Exposure Uptake Biokinetic Model' is utilized. To assess the health risk of chronic usage both for children and adults, oral daily systemic exposure levels are calculated with the worst-case scenario and are compared with Maximum Allowable Dose Level for lipsticks. For lifetime risk assessment, exposure is assumed to start by age 7, and four different exposure scenarios have been deployed.Results The mean lead content of lipsticks shows significant statistical differences between the high- and low-priced lipstick groups. Daily level and total risk for lifetime Pb exposure from deployed lipsticks are below the acceptable risk levels but long-worn usage of products with routine monitoring of metal content is crucial for sensitive and unintended exposure groups.
引用
收藏
页码:335 / 341
页数:7
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