Assessing the efficacy of topical formulations in diabetic neuropathy: a narrative review

被引：0

作者：

Elbeddini, Ali ^{[1
]}

Tanvir, Azasma ^{[2
]}

Yilmaz, Orhan ^{[2
]}

Rahman, Yusra ^{[3
]}

Mongon, Renata ^{[4
]}

机构：

[1] Univ Ottawa, Sch Med, Family Med Dept, 600 Peter Morand Crescent Suite 201, Ottawa, ON K1G 5Z3, Canada

[2] Univ Saskatchewan, Coll Med, 107 Wiggins Rd, Saskatoon, SK S7N 5E5, Canada

[3] McMaster Univ, Fac Hlth Sci, 1280 Main St West, Hamilton, ON L8S 4L8, Canada

[4] Univ Estadual Campinas, Anesthesiol Dept, Campinas, Brazil

来源：

JOURNAL OF DIABETES AND METABOLIC DISORDERS | 2024年 / 23卷 / 02期

关键词：

Localized neuropathic pain; Compounding services; Patient safety; LIDOCAINE MEDICATED PLASTER; CAPSAICIN 8-PERCENT PATCH; POSTHERPETIC NEURALGIA; PERIPHERAL NEUROPATHY; DOUBLE-BLIND; OPEN-LABEL; 5-PERCENT; PAIN; GABAPENTIN; PREGABALIN;

D O I：

10.1007/s40200-024-01459-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BackgroundWe conducted a review of topical medications available for alleviation of diabetic neuropathic pain (DNP) and compared their efficacy with oral medications for pain relief. We also explored the feasibility of compounding topical medications.MethodsSearches on PubMed, Medline Ovid, and Embase databases were conducted and findings were presented as a narrative review.Results and discussion8% Capsaicin patches and 5% Lidocaine patches had the most evidence. The literature also showed evidence for topical clonidine, gabapentin, and amitriptyline.ConclusionTopical formulations are a potential substitute to oral medications in patients suffering from DNP. Potential options include 8% Capsaicin patch, 5% Lidocaine patch, Clonidine gel, Topical gabapentin, and an amitriptyline and ketamine combination. A promising area of research that requires further study is the effect of a combination of topicals in alleviated DNP.

引用

页码：1613 / 1620

页数：8

共 50 条

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