Role of electrophysiological activity and interactions of lateral habenula in the development of depression-like behavior in a chronic restraint stress model

被引:0
作者
Wang, Chang [1 ,2 ,3 ,5 ]
Sun, Yuting [1 ,2 ,3 ,5 ]
Xing, Yanjie [1 ,2 ,3 ,5 ]
Liu, Kezhou [4 ]
Xu, Kedi [1 ,2 ,3 ,5 ]
机构
[1] Zhejiang Univ, Qiushi Acad Adv Studies QAAS, Hangzhou 310027, Peoples R China
[2] Nanhu Brain Comp Interface Inst, Hangzhou 311100, Peoples R China
[3] Zhejiang Univ, Dept Biomed Engn, Zhejiang Prov Key Lab Cardiocerebral Vasc Detect T, Key Lab Biomed Engn,Educ Minist, Hangzhou, Peoples R China
[4] Hangzhou Dianzi Univ, Sch Automat Artificial Intelligence, Hangzhou 310018, Peoples R China
[5] Zhejiang Univ, State Key Lab Brain Machine Intelligence, Hangzhou, Peoples R China
关键词
Local field potential; Depression; Chronic restraint stress; Lateral habenula; Functional Connectivity; Graph theory; DEEP BRAIN-STIMULATION; TREATMENT-RESISTANT DEPRESSION; GRAPH-THEORETICAL ANALYSIS; MEDIAL FOREBRAIN-BUNDLE; NUCLEUS-ACCUMBENS; ANXIETY-LIKE; DYNAMICS; BETA; CONNECTIVITY; POTENTIALS;
D O I
10.1016/j.brainres.2024.148914
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Closed-loop deep brain stimulation (DBS) system offers a promising approach for treatment-resistant depression, but identifying universally accepted electrophysiological biomarkers for closed-loop DBS systems targeting depression is challenging. There is growing evidence suggesting a strong association between the lateral habenula (LHb) and depression. Here, we took LHb as a key target, utilizing multi-site local field potentials (LFPs) to study the acute and chronic changes in electrophysiology, functional connectivity, and brain network characteristics during the formation of a chronic restraint stress (CRS) model. Furthermore, our model combining the electrophysiological changes of LHb and interactions between LHb and other potential targets of depression can effectively distinguish depressive states, offering a new way for developing effective closed-loop DBS strategies.
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页数:10
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