Age-related Differences in Spatially Resolved Transcriptomic Profiles of Patients With Hormone Receptor-positive Breast Carcinoma

被引：1
作者：
Chu, Jinah [1 ]
Do, Sung -im [1 ]
Kim, Hyun-soo [2 ]
机构：
[1] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Pathol, 29 Saemunan ro, Seoul 03181, South Korea
[2] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Pathol & Translat Genom, 81 Irwon ro, Seoul 06351, South Korea
来源：
ANTICANCER RESEARCH | 2024年 / 44卷 / 06期
基金：
新加坡国家研究基金会;
关键词：
Breast; young-age breast carcinoma; spatial transcriptomics; MESONEPHRIC-LIKE ADENOCARCINOMA; RECURRENCE SCORE; GENE; METASTASIS; DIAGNOSIS; PATTERNS; SURVIVAL; THERAPY; SURGERY; ASSAY;
D O I：
10.21873/anticanres.17066
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background/Aim: Patients' age may influence the response to chemotherapy and the clinical course of breast carcinoma. This study aimed to compare the spatial transcriptomic profiles between younger ( <= 50 years) and older (>50 years) patients with hormone receptor (HR)positive breast carcinoma. Patients and Methods: Seven cases of breast carcinoma were included. We performed digital spatial profiling and bioinformatic analysis to investigate the spatial transcriptomes of the epithelial and stromal compartments. Results: In the epithelial compartment of three young-age breast carcinoma (YABC) cases, we found 21 up-regulated and 7 down-regulated genes. The top two most upregulated genes were serpin peptidase inhibitor clade A member 1 and serine protease. The gene ontology enrichment analysis revealed a significant up-regulation of genes defining ribosomal structures and functions in YABCs. The gene set enrichment analysis revealed that gene sets defining early and late responses to estrogen, response to interferon-alpha , and tumor necrosis factor-alpha signaling were significantly enriched in YABCs. Conclusion: We described for the first time the age-related differences in spatially resolved transcriptomic profiles and up-regulated transcriptional pathways of HR-positive breast carcinoma. Our observations highlight the critical need for age-specific treatment strategies for breast carcinoma management.
引用
收藏
页码：2605 / 2616
页数：12
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