Curcumin mitigates ochratoxin A-induced oxidative stress and alters gene expression in broiler chicken liver and kidney

被引:3
作者
Kovesi, Benjamin [1 ]
Worlanyo, Adanu Paul [1 ]
Kulcsar, Szabina [2 ]
Ancsin, Zsolt [1 ]
Erdelyi, Marta [1 ]
Zandoki, Erika [2 ]
Mezes, Miklos [1 ,2 ]
Balogh, Krisztian [1 ,2 ]
机构
[1] Hungarian Univ Agr & Life Sci, Inst Physiol & Nutr, Dept Feed Safety, Szent Istvan Campus, H-2100 Godollo, Hungary
[2] Hungarian Univ Agr & Life Sci, HUN REN MATE Mycotoxins Food Chain Res Grp, H-7400 Kaposvar, Hungary
关键词
ochratoxin A; curcumin; glutathione-peroxidase; aryl hydrocarbon receptor; oxidative stress; gene expression; MYCOTOXIN; FACTOR-2; CELL;
D O I
10.1556/004.2024.01016
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
The study aimed to evaluate the effect of curcumin (CURC) supplementation on broiler chickens exposed to ochratoxin A (OTA), by examining biochemical parameters and the expression of glutathione redox system genes and their regulation. OTA reduced glutathione content in the liver while increasing glutathione peroxidase activity. CURC showed no significant effects. Kidney parameters remained mostly unaffected. Gene expression analysis revealed OTA-induced upregulation of KEAP1, NRF2, AHR, GPx4 and GSR genes in the liver. CURC supplementation led to the upregulation of GPx4 and AHR genes with OTA+CURC treatment, resulting in the downregulation of GPx4, KEAP1, NRF2 and AHR genes compared to OTA treatment alone. In the kidney, GPx4 was downregulated, and NRF2 and AHR were upregulated as an effect of OTA, while CURC upregulated the NRF2 gene only. OTA+CURC treatment led to the downregulation of GPx4, GSS and AHR genes compared to the control and downregulation of NRF2 and AHR genes compared to OTA. The results suggested that CURC is partly effective against OTA-induced oxidative stress and that the effect of OTA and CURC on the antioxidant response is regulated through the KEAP1-NRF2-ARE and AHR pathways.
引用
收藏
页码:41 / 50
页数:10
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