An Atherosclerosis Indicator Hyaluronic Acid: Can Plasma Hyaluronic Acid Be Useful in Diagnosing Alzheimer's Disease?

被引：0

作者：

Ceylan, Serdar ^{[1
]}

Guner, Merve ^{[1
]}

Okyar-Bas, Arzu ^{[1
]}

Kahyaoglu, Zeynep ^{[1
]}

Koc, Neriman S. ^{[2
]}

Koksal, Gamze N. ^{[3
]}

Kiran, Yasin ^{[3
]}

Sagir, Aykut ^{[1
]}

Balci, Cafer ^{[1
]}

Halil, Meltem G. ^{[1
]}

Cankurtaran, Mustafa ^{[1
]}

Yildirim, Tolga ^{[2
]}

Lay, Incilay ^{[4
]}

Dogu, Burcu B. ^{[1
]}

机构：

[1] Hacettepe Univ, Fac Med, Dept Internal Med, Div Geriatr, TR-06230 Ankara, Turkiye

[2] Hacettepe Univ, Fac Med, Dept Internal Med, Div Nephrol, Ankara, Turkiye

[3] Hacettepe Univ Hosp Labs, Ankara, Turkiye

[4] Hacettepe Univ, Fac Med, Dept Med Biochem, Ankara, Turkiye

来源：

CLINICAL LABORATORY | 2024年 / 70卷 / 03期

关键词：

Alzheimer's disease; arterial stiffness; hyaluronic acid; MILD COGNITIVE IMPAIRMENT; ARTERIAL STIFFNESS; ENDOTHELIAL GLYCOCALYX; CEREBROSPINAL-FLUID; SHORT-FORM; RISK; GLYCOSAMINOGLYCANS; VALIDATION; BRAIN; INDEX;

D O I：

10.7754/Clin.Lab.2023.230734

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background: The aim is to compare the plasma levels of hyaluronic acid (HA) which is closely related to inflammation and vascular changes and arterial stiffness (AS) related values in patients with Alzheimer's disease (AD), amnestic type mild cognitive impairment (aMCI), and normal cognitive functions (NCF). Methods: Ninety participants were categorized into three groups, patients with AD, MCI, and NCF. Arterial stiffness measurement in the nephrology outpatient clinic, and storage and analysis of plasma samples in the biochemistry laboratory. Results: Of the 90 patients, 32 had NCF, 32 had aMCI, and 26 had AD. Between groups, there was no difference in HA, pulse wave velocity, and augmentation index. The HA level had no statistically significant correlation with any of the other variables. Conclusions: Plasma HA levels will not be useful in the diagnosis of AD. More comprehensive studies with larger number of patients are needed. (Clin. Lab. 2024;70:510-516. DOI: 10.7754/Clin.Lab.2023.230734)

引用

页码：510 / 516

页数：7

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