Combination of reduced post-transplant cyclophosphamide and early tacrolimus initiation increases the incidence of chronic graft-versus-host disease in human leukocyte antigen-haploidentical peripheral blood stem-cell transplantation

被引：0

作者：

Terao, Toshiki ^{[1
]}

Kondo, Takumi ^{[1
]}

Nakamura, Makoto ^{[1
]}

Takasuka, Hiroki ^{[1
]}

Fujiwara, Hideaki ^{[1
]}

Asada, Noboru ^{[1
]}

Ennishi, Daisuke ^{[1
]}

Nishimori, Hisakazu ^{[1
]}

Fujii, Keiko ^{[1
,2
]}

Fujii, Nobuharu ^{[1
,3
]}

Maeda, Yoshinobu ^{[1
]}

Matsuoka, Ken-ichi ^{[1
]}

机构：

[1] Okayama Univ Hosp, Dept Hematol & Oncol, 2-5-1 Shikata Cho,Kita Ku, Okayama, Okayama 7008558, Japan

[2] Okayama Univ Hosp, Div Clin Lab, Okayama, Japan

[3] Okayama Univ Hosp, Div Blood Transfus, Okayama, Japan

来源：

EJHAEM | 2024年 / 5卷 / 04期

关键词：

chronic GVHD; haploidentical; hematopoietic stem-cell transplantation; PTCy; tacrolimus;

D O I：

10.1002/jha2.962

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We evaluated the clinical impacts of the concurrent modification of post-transplant cyclophosphamide (PTCy) dose and tacrolimus (Tac)-initiation timing in 61 patients with human leukocyte antigen-haploidentical transplantation. Reduced-dose PTCy (80 mg/kg) was associated with a higher incidence of moderate-to-severe chronic graft-versus-host disease (GVHD) than standard-dose PTCy (100 mg/kg) (35.0% vs. 26.6%, p = 0.053). Notably, early-initiation Tac (day -1) increased moderate-to-severe chronic GVHD than standard-initiation Tac (day 5) in the reduced-dose PTCy group (p = 0.032), whereas Tac-initiation timing did not impact chronic GVHD in the standard-dose PTCy group. These data indicate that the combination of reduced-dose PTCy and early-initiation Tac can amplify chronic GVHD.

引用

页码：810 / 814

页数：5

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