Fatality owing to pulmonary hemorrhage following pamidronate disodium administration in a neonate with osteogenesis imperfecta type 2: A case report

被引：0

作者：

Nagoshi, Rintaro ^{[1
]}

Amari, Shoichiro ^{[1
,2
]}

Abiko, Yu ^{[3
]}

Wada, Yuka Sano ^{[1
,2
]}

Ishiguro, Akira ^{[1
]}

Horikawa, Reiko ^{[4
]}

Ito, Yushi ^{[2
]}

机构：

[1] Natl Ctr Child Hlth & Dev, Ctr Postgrad Educ & Training, Tokyo, Japan

[2] Natl Ctr Child Hlth & Dev, Ctr Maternal Fetal Neonatal & Reprod Med, Div Neonatol, 2-10-1 Okura,Setagaya Ku, Tokyo 1578535, Japan

[3] Yamagata Univ Hosp, Dept Pediat, Yamagata, Japan

[4] Natl Ctr Child Hlth & Dev, Div Endocrinol & Metab, Tokyo, Japan

来源：

CLINICAL PEDIATRIC ENDOCRINOLOGY | 2024年 / 33卷 / 02期

关键词：

pamidronate disodium; bisphosphonates; osteogenesis imperfecta; pulmonary hemorrhage; CHILDREN; ACETAMINOPHEN; MANAGEMENT; VARIANTS; THERAPY; BONE;

D O I：

10.1297/cpe.33.2023-0061

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report the case of a patient with osteogenesis imperfecta (OI) who developed pulmonary hemorrhage 4 d after pamidronate disodium (PA) administration, despite a relatively stable respiratory status. Bisphosphonates are introduced to reduce osteoclast activity and are now widely used in patients with OI. Bisphosphonates are typically well -tolerated in children, and the standard of care involves cyclic intravenous administration of PA. However, in practice, there is limited experience with the use of PA for severe OI during the neonatal period, and its safety remains uncertain. This report aimed to describe the respiratory events potentially associated with PA in a neonatal patient with OI type 2, suggesting that serious life -threatening complications of pulmonary hemorrhage may occur after PA administration. Further studies are required to assess the relationship between pulmonary hemorrhage and PA administration, aiming to enhance prophylaxis measures.

引用

页码：76 / 81

页数：6