Seroprevalence of SARS-CoV-2 Antibodies and Associated Factors in Bamako, Mali: A Population-Based Cross-Sectional Study in September 2022

被引：0

作者：

Traore, Bourama ^{[1
]}

Guindo, Merepen A. ^{[1
]}

Konate, Drissa ^{[1
]}

Kane, Fousseyni ^{[1
]}

Incandela, Nathan C. ^{[2
]}

Traore, Abdouramane ^{[1
]}

Kante, Salimata ^{[1
]}

Sidibe, Mariam ^{[1
]}

Keita, Bourama ^{[1
]}

Kasse, Fatoumata ^{[1
]}

Tangara, Karamoko ^{[1
]}

Diallo, Dramane ^{[1
]}

Maiga, Issoufi Y. ^{[1
]}

Thiam, Salif ^{[1
]}

Cisse, Abdourhamane ^{[1
]}

Siby, Khatry M. ^{[1
]}

Dicko, Abdoul R. ^{[3
]}

Goita, Mariam ^{[3
]}

Kone, Diakaridia ^{[4
]}

Diallo, Mamadou ^{[5
]}

Traore, Modibo ^{[6
]}

Coulibaly, Yaya I. ^{[1
]}

Diakite, Mahamadou ^{[1
]}

Doumbia, Seydou ^{[1
]}

Dolo, Housseini ^{[1
]}

Balam, Saidou ^{[1
]}

机构：

[1] Univ Sci Tech & Technol Bamako USTTB, Univ Clin Res Ctr UCRC, Int Ctr Excellence Res ICER, Fac Med & Odontostomatol FMOS,Fac Pharm FAPHA, Bamako, Mali

[2] Univ Calif Santa Barbara, Ctr Polymers & Organ Solids, Dept Chem & Biochem, Santa Barbara, CA USA

[3] Dist Hlth Ctr Commune 4 Bamako, Minist Hlth & Social Dev Mali, Bamako, Mali

[4] Hosp Dist Hlth Commune 1 Bamako, Minist Hlth & Social Dev Mali, Bamako, Mali

[5] Dist Hlth Ctr Commune 6 Bamako, Minist Hlth & Social Dev Mali, Bamako, Mali

[6] Dist Hlth Ctr Commune 5 Bamako, Minist Hlth & Social Dev Mali, Bamako, Mali

来源：

INFLUENZA AND OTHER RESPIRATORY VIRUSES | 2024年 / 18卷 / 07期

关键词：

associated factors; Bamako; Mali; SARS-CoV-2; antibodies; seroprevalence; COVID-19; SEX;

D O I：

10.1111/irv.13343

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

BackgroundThe sero-epidemiological characteristics of SARS-CoV-2 infections in Mali are not yet well understood. This study assessed SARS-CoV-2 antibody seroprevalence and factors associated with antibody responses in the general population of Bamako, the capital city and epicenter of COVID-19, to assess the magnitude of the pandemic and contribute to control strategy improvements in Mali.MethodsA cross-sectional survey was conducted in September 2022 to collect sociodemographic information, clinical characteristics, comorbid factors, and blood samples. ELISA was performed to determine anti-Spike (anti-S) and anti-RBD antibody levels. A total of 3601 participants were enrolled in REDCap. R-Studio was used for the statistical analysis. The chi-squared (chi 2) test was used to compare the proportions across different groups. Logistic regression models were used to elucidate factors associated with antibody responses.ResultThe sex ratio for female-to-male was 3.6:1. The most representative groups were the 20-29-year-olds (28.9%, n = 1043) and the 30-39-year-olds (26.9%, n = 967). The COVID-19 vaccine coverage among the participants was 35.8%, with vaccines from Covishield AstraZeneca (13.4%), Johnson & Johnson (16.7%), Sinovac (3.9%), and BioNTech Pfizer (1.8%). Overall, S protein and RBD antibody seroprevalences were remarkably high in the study population (98% and 97%, respectively). Factors such as youth (1-9 years old) and male sex were associated with lower SARS-CoV-2 antibody responses, whereas COVID-19 vaccinations were associated with increased antibody responses.ConclusionThis serosurvey demonstrated the high seroprevalence of SARS-CoV-2 antibodies and highlighted the factors influencing antibody responses, while clearly underlining an underestimation of the pandemic in Mali.

引用

页数：11

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