Degradable Microneedle Patch with Photothermal-Promoted Bacteria-Infected Wound Healing and Microenvironment Remodeling

被引：3
作者：
Yin, Xinjie [1 ]
Wei, Jie [1 ]
Hou, Jinhong [1 ]
Xu, Suying [1 ]
Wang, Leyu [1 ]
机构：
[1] Beijing Univ Chem Technol, Coll Chem, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China
来源：
ACS APPLIED MATERIALS & INTERFACES | 2024年 / 16卷 / 25期
基金：
中国国家自然科学基金;
关键词：
Microneedle; Photothermal; Wound healing; Antibacterial effect; Microenvironment remodeling; NANOPARTICLES;
D O I：
10.1021/acsami.4c04414
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Bacteria-infected wound healing is one of the most challenging issues in health management that is attracting worldwide concerns. Despite great achievements with antibiotics, emergence of antibiotic-resistance retarded the wound healing process and also led to severe outcomes. Exploration of novel antibiotics together with amelioration of wound healing efficacy is desirable. Herein, a degradable microneedle patch (AAZH@MNs) was fabricated through incorporating near-infrared light responsive photothermal agents for sustained bacteria killing and prevention of biofilm formation. In addition, the antibacterial microneedle patch could even remold the microenvironment of bacteria-infected wounds through an antibacterial effect, significantly facilitating the wound healing process.
引用
收藏
页码：32017 / 32026
页数：10
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