Advancements in Utilizing Natural Compounds for Modulating Autophagy in Liver Cancer: Molecular Mechanisms and Therapeutic Targets

被引:1
|
作者
Rahman, Md Ataur [1 ]
Rakib-Uz-Zaman, S. M. [2 ,3 ]
Chakraborti, Somdeepa [2 ]
Bhajan, Sujay Kumar [4 ]
Gupta, Rajat Das [5 ]
Jalouli, Maroua [6 ]
Parvez, Md. Anowar Khasru [7 ]
Shaikh, Mushfiq H. [8 ]
Apu, Ehsanul Hoque [9 ,10 ,11 ]
Harrath, Abdel Halim [12 ]
Moon, Seungjoon [13 ]
Kim, Bonglee [13 ,14 ]
机构
[1] Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA
[2] Univ Delaware, Dept Biol Sci, Newark, DE 19716 USA
[3] BRAC Univ, Sch Data & Sci, Dept Math & Nat Sci, Biotechnol Program, Dhaka 1212, Bangladesh
[4] Bangabandhu Sheikh Mujibur Rahman Sci & Technol Un, Dept Biotechnol & Genet Engn, Gopalganj 8100, Bangladesh
[5] Univ South Carolina, Arnold Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC 29208 USA
[6] Imam Mohammad Ibn Saud Islamic Univ IMSIU, Coll Sci, Dept Biol, Riyadh 11623, Saudi Arabia
[7] Jahangirnagar Univ, Dept Microbiol, Savar 1342, Bangladesh
[8] Western Univ, Dept Otolaryngol Head & Neck Surg, London, ON N6A 4V2, Canada
[9] Lincoln Mem Univ, Coll Dent Med, Dept Biomed Sci, Knoxville, TN 37923 USA
[10] Lincoln Mem Univ, DeBusk Coll Osteopath Med, Harrogate, TN 37752 USA
[11] Univ Michigan, Dept Internal Med, Div Hematol & Oncol, Michigan Med, Ann Arbor, MI 48109 USA
[12] King Saud Univ, Coll Sci, Zool Dept, Riyadh 11451, Saudi Arabia
[13] Kyung Hee Univ, Coll Korean Med, Dept Pathol, 1-5 Hoegidong, Seoul 02447, South Korea
[14] Kyung Hee Univ, Coll Korean Med, Korean Med Based Drug Repositioning Canc Res Ctr, Seoul 02447, South Korea
基金
新加坡国家研究基金会;
关键词
autophagy; homeostasis; natural compound; hepatocellular carcinoma; cancer therapy; HUMAN HEPATOCELLULAR-CARCINOMA; IN-VITRO; SIGNALING PATHWAY; BETULINIC ACID; MACROPHAGE POLARIZATION; MEDIATED APOPTOSIS; RESVERATROL EXERTS; CELL-DEATH; EMODIN; INDUCTION;
D O I
10.3390/cells13141186
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Autophagy, an intrinsic catabolic mechanism that eliminates misfolded proteins, dysfunctional organelles, and lipid droplets, plays a vital function in energy balance and cytoplasmic quality control, in addition to maintaining cellular homeostasis. Liver cancer such as hepatocellular carcinoma (HCC) is one of the most common causes of cancer deaths globally and shows resistance to several anticancer drugs. Despite the rising incidence and poor prognosis of malignant HCC, the underlying molecular mechanisms driving this aggressive cancer remain unclear. Several natural compounds, such as phytochemicals of dietary and non-dietary origin, affect hepatocarcinogenesis signaling pathways in vitro and in vivo, which may help prevent and treat HCC cells. Current HCC cells treatments include chemotherapy, radiation, and surgery. However, these standard therapies have substantial side effects, and combination therapy enhances side effects for an acceptable therapeutic benefit. Therefore, there is a need to develop treatment strategies for HCC cells that are more efficacious and have fewer adverse effects. Multiple genetic and epigenetic factors are responsible for the HCC cells to become resistant to standard treatment. Autophagy contributes to maintain cellular homeostasis, which activates autophagy for biosynthesis and mitochondrial regulation and recycling. Therefore, modifying autophagic signaling would present a promising opportunity to identify novel therapies to treat HCC cells resistant to current standard treatments. This comprehensive review illustrates how natural compounds demonstrate their anti-hepatocellular carcinoma function through autophagy.
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页数:24
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