Multifunctional hydrogel combined with electrical stimulation therapy for promoting diabetic wound healing

被引：11

作者：

Zheng, Xiaoyan ^{[1
]}

Yao, Jiaxin ^{[1
,2
]}

Yao, Jialing ^{[2
,3
]}

Wang, Pan ^{[2
]}

Liu, Wan ^{[1
,2
]}

Fan, Daidi ^{[1
,2
,3
]}

Hui, Junfeng ^{[1
,2
,3
]}

机构：

[1] Northwest Univ, Engn Res Ctr Western Resource Innovat Med Green Mf, Sch Chem Engn, Minist Educ, Xian 710127, Peoples R China

[2] Northwest Univ, Shaanxi R&D Ctr Biomat & Fermentat Engn, Sch Chem Engn, Shaanxi Key Lab Biomat & Synthet Biol, Xian 710127, Peoples R China

[3] Northwest Univ, Biotech & Biomed Res Inst, Xian 710127, Peoples R China

来源：

NANO RESEARCH | 2024年 / 17卷 / 11期

基金：

中国国家自然科学基金;

关键词：

hydrogel dressing; diabetic wound healing; antibacterial; antioxidant; electrical stimulation therapy;

D O I：

10.1007/s12274-024-6943-4

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Diabetic wounds, as a complication of diabetes, are slow to heal and seriously affect the quality of life of patients. Functional hydrogel dressing is an effective approach to improve diabetic wound healing. Electrical stimulation (ES) therapy is conducive to promoting cell migration and wound healing. In this work, a multifunctional PPTZ hydrogel wound dressing was developed by freeze-thaw method with polyvinyl alcohol (PVA), phytic acid (PA), tannic acid (TA), and Zinc chloride. The obtained PPTZ hydrogel has good mechanical properties (stress and strain of 700.03 kPa and 575.08%), light transmittance (close to 100%) and antibacterial rate (over 75%). With good biocompatibility, antioxidant abilities and conductivity, the PPTZ hydrogel could effectively promote the healing of diabetic wounds with two weeks under the action of electric field, which provides an auxiliary treatment strategy for diabetic patients.

引用

页码：9942 / 9953

页数：12

共 44 条

[1] High-strength, antibacterial, antioxidant, hemostatic, and biocompatible chitin/PEGDE-tannic acid hydrogels for wound healing [J].