Targeting the Hippo Pathway in Cutaneous Melanoma

被引：1

作者：

Kazimierczak, Urszula ^{[1
]}

Przybyla, Anna ^{[1
]}

Smielowska, Marianna ^{[2
]}

Kolenda, Tomasz ^{[3
,4
]}

Mackiewicz, Andrzej ^{[1
,5
]}

机构：

[1] Poznan Univ Med Sci, Dept Canc Immunol, Rokietnicka St 8, PL-61806 Poznan, Poland

[2] Polish Acad Sci, Inst Bioorgan Chem, Dept Genome Engn, Z Noskowskiego 12-14, PL-61704 Poznan, Poland

[3] Greater Poland Canc Ctr, Lab Canc Genet, Garbary 15, PL-61866 Poznan, Poland

[4] Greater Poland Canc Ctr, Res & Implementat Unit, Garbary 15, PL-61866 Poznan, Poland

[5] Greater Poland Canc Ctr, Dept Canc Diagnost & Immunol, Garbary St 15, PL-61866 Poznan, Poland

来源：

CELLS | 2024年 / 13卷 / 12期

关键词：

cutaneous melanoma; Hippo pathway; therapeutic targets; BRAF INHIBITOR RESISTANCE; ORGAN SIZE CONTROL; SIGNALING-PATHWAY; CELL-PROLIFERATION; TUMOR-SUPPRESSOR; NUCLEAR TRANSLOCATION; CONTACT INHIBITION; CASPASE CLEAVAGE; YAP; KINASE;

D O I：

10.3390/cells13121062

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Melanoma is the most aggressive form of skin cancer. In the advanced stage of development, it is resistant to currently available therapeutic modalities. Increased invasiveness and metastatic potential depend on several proteins involved in various signal transduction pathways. Hippo signaling plays a vital role in malignant transformation. Dysfunctions of the Hippo pathway initiate the expression of tumor growth factors and are associated with tumor growth and metastasis formation. This review summarizes the recent achievements in studying the role of the Hippo pathway in melanoma pathogenesis and points to the potential specific targets for anti-melanoma therapy.

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页数：15

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