Research Priorities on the Role of α-Synuclein in Parkinson's Disease Pathogenesis

被引：6

作者：

Burre, Jacqueline ^{[1
,2
]}

Edwards, Robert H. ^{[3
]}

Halliday, Glenda ^{[4
]}

Lang, Anthony E. ^{[5
,6
]}

Lashuel, Hilal A. ^{[7
]}

Melki, Ronald ^{[8
,9
]}

Murayama, Shigeo ^{[10
,11
]}

Outeiro, Tiago F. ^{[12
,13
]}

Papa, Stella M. ^{[14
,15
]}

Stefanis, Leonidas ^{[16
,17
]}

Woerman, Amanda L. ^{[18
,19
]}

Surmeier, Dalton James ^{[20
,21
]}

Kalia, Lorraine V. ^{[5
,6
]}

Takahashi, Ryosuke ^{[22
]}

机构：

[1] Weill Cornell Med, Appel Inst Alzheimers Dis Res, New York, NY USA

[2] Weill Cornell Med, Brain & Mind Res Inst, New York, NY USA

[3] Univ Calif San Francisco, Sch Med, Dept Physiol & Neurol, San Francisco, CA USA

[4] Univ Sydney, Brain & Mind Ctr, Sch Med Sci, Camperdown, NSW, Australia

[5] Univ Hlth Network, Toronto Western Hosp, Krembil Res Inst, Edmond J Safra Program Parkinsons Dis, 399 Bathurst St, Toronto, ON, Canada

[6] Univ Toronto, Dept Med, Div Neurol, Toronto, ON, Canada

[7] Ecole Polytech Fed Lausanne EPFL, Brain Mind Inst, Lab Chem Biol Neurodegenerat, Lausanne, Switzerland

[8] CNRS, Inst Francois Jacob MIRCen, CEA, Fontenay Aux Roses, France

[9] CNRS, Lab Neurodegenerat Dis, Fontenay Aux Roses, France

[10] Tokyo Metropolitan Inst Geriatr & Gerontol, Dept Neuropathol, Tokyo, Japan

[11] Osaka Univ, United Grad Sch Child Dev, Brain Bank Neurodev Neurol & Psychiat Disorders, Osaka, Japan

[12] Univ Med Ctr, Dept Expt Neurodegenerat, Gottingen, Germany

[13] Newcastle Univ, Translat & Clin Res Inst, Fac Med Sci, Newcastle Upon Tyne, England

[14] Emory Univ, Sch Med, Dept Neurol, Atlanta, GA USA

[15] Emory Univ, Emory Natl Primate Res Ctr, Atlanta, GA USA

[16] Natl & Kapodistrian Univ Athens, Eginitio Hosp, Sch Med, Dept Neurol 1, Athens, Greece

[17] Acad Athens, Biomed Res Fdn, Athens, Greece

[18] Univ Massachusetts, Inst Appl Life Sci, Dept Biol, Amherst, MA USA

[19] Colorado State Univ, Prion Res Ctr, Dept Microbiol Immunol & Pathol, Ft Collins, CO USA

[20] Northwestern Univ, Feinberg Sch Med, Dept Neurosci, Chicago, IL USA

[21] Aligning Sci Parkinsons ASAP Collaborat Res Networ, Chevy Chase, MD USA

[22] Kyoto Univ, Grad Sch Med, Dept Neurol, Yoshida Konoe Cho,Sakyo Ku, Kyoto 6068501, Japan

来源：

MOVEMENT DISORDERS | 2024年 / 39卷 / 10期

关键词：

alpha-synuclein; Lewy pathology; neurodegeneration; pathogenesis; protein aggregation; INCIDENTAL LEWY BODY; HEPARAN-SULFATE PROTEOGLYCANS; MEMBRANE-BINDING; AMPLIFICATION ASSAYS; SYNAPTIC DYSFUNCTION; NIGROSTRIATAL SYSTEM; PREFORMED FIBRILS; GAMMA-SYNUCLEIN; UP-REGULATION; A-SYNUCLEIN;

D O I：

10.1002/mds.29897

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Various forms of Parkinson's disease, including its common sporadic form, are characterized by prominent alpha-synuclein (alpha Syn) aggregation in affected brain regions. However, the role of alpha Syn in the pathogenesis and evolution of the disease remains unclear, despite vast research efforts of more than a quarter century. A better understanding of the role of alpha Syn, either primary or secondary, is critical for developing disease-modifying therapies. Previous attempts to hone this research have been challenged by experimental limitations, but recent technological advances may facilitate progress. The Scientific Issues Committee of the International Parkinson and Movement Disorder Society (MDS) charged a panel of experts in the field to discuss current scientific priorities and identify research strategies with potential for a breakthrough. (c) 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

引用

页码：1663 / 1678

页数：16

共 194 条

[41] Direct detection of alpha synuclein oligomers in vivo
Dimant H.
Kalia S.K.
Kalia L.V.
Zhu L.N.
Kibuuka L.
Ebrahimi-Fakhari D.
McFarland N.R.
Fan Z.
Hyman B.T.
McLean P.J.
[J]. Acta Neuropathologica Communications, 1 (1)
[42] Donzelli S., 2023, BIORXIV, V2023
[43] Conformational properties of α-synuclein in its free and lipid-associated states
Eliezer, D
Kutluay, E
Bussell, R
Browne, G
[J]. JOURNAL OF MOLECULAR BIOLOGY, 2001, 307 (04) : 1061 - 1073
[44] Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases
Espay, Alberto J.
Vizcarra, Joaquin A.
Marsili, Luca
Lang, Anthony E.
Simon, David K.
Merola, Aristide
Josephs, Keith A.
Fasano, Alfonso
Morgante, Francesca
Savica, Rodolfo
Greenamyre, J. Timothy
Cambi, Franca
Yamasaki, Tritia R.
Tanner, Caroline M.
Gan-Or, Ziv
Litvan, Irene
Mata, Ignacio F.
Zabetian, Cyrus P.
Brundin, Patrik
Fernandez, Hubert H.
Standaert, David G.
Kauffman, Marcelo A.
Schwarzschild, Michael A.
Sardi, S. Pablo
Sherer, Todd
Perry, George
Leverenz, James B.
[J]. NEUROLOGY, 2019, 92 (07) : 329 - 337
[45] Reverse engineering Lewy bodies: how far have we come and how far can we go?
Fares, Mohamed Bilal
Jagannath, Somanath
Lashuel, Hilal A.
[J]. NATURE REVIEWS NEUROSCIENCE, 2021, 22 (02) : 111 - 131
[46] The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear localization in cells
Fares, Mohamed-Bilal
Ait-Bouziad, Nadine
Dikiy, Igor
Mbefo, Martial K.
Jovicic, Ana
Kiely, Aoife
Holton, Janice L.
Lee, Seung-Jae
Gitler, Aaron D.
Eliezer, David
Lashuel, Hilal A.
[J]. HUMAN MOLECULAR GENETICS, 2014, 23 (17) : 4491 - 4509
[47] Functional and neuropathological changes induced by injection of distinct alpha-synuclein strains: A pilot study in non-human primates
Fayard, Audrey
Fenyi, Alexis
Lavisse, Sonia
Dovero, Sandra
Bousset, Luc
Bellande, Tracy
Lecourtois, Sophie
Jouy, Christophe
Guillermier, Martine
Jan, Caroline
Gipchtein, Pauline
Dehay, Benjamin
Bezard, Erwan
Melki, Ronald
Hantraye, Philippe
Badin, Romina Aron
[J]. NEUROBIOLOGY OF DISEASE, 2023, 180
[48] Behavioral and histopathological consequences of paraquat intoxication in mice:: Effects of α-synuclein over-expression
Fernagut, P. O.
Hutson, C. B.
Fleming, S. M.
Tetreaut, N. A.
Salcedo, J.
Masliah, E.
Chesselet, M. F.
[J]. SYNAPSE, 2007, 61 (12) : 991 - 1001
[49] Modulation of alpha-synuclein toxicity in yeast using a novel microfluidic-based gradient generator
Fernandes, Joao Tiago S.
Tenreiro, Sandra
Gameiro, Andreia
Chu, Virginia
Outeiro, Tiago F.
Conde, Joao P.
[J]. LAB ON A CHIP, 2014, 14 (20) : 3949 - 3957
[50] A new alpha-synuclein missense variant (Thr72Met) in two Turkish families with Parkinson's disease
Fevga, Christina
Park, Yangshin
Lohmann, Ebba
Kievit, Anneke J.
Breedveld, Guido J.
Ferraro, Federico
de Boer, Leon
van Minkelen, Rick
Hanagasi, Hasmet
Boon, Agnita
Wang, Wei
Petsko, Gregory A.
Hoang, Quyen Q.
Emre, Murat
Bonifati, Vincenzo
[J]. PARKINSONISM & RELATED DISORDERS, 2021, 89 : 63 - 72

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