Research Priorities on the Role of α-Synuclein in Parkinson's Disease Pathogenesis

被引：6

作者：

Burre, Jacqueline ^{[1
,2
]}

Edwards, Robert H. ^{[3
]}

Halliday, Glenda ^{[4
]}

Lang, Anthony E. ^{[5
,6
]}

Lashuel, Hilal A. ^{[7
]}

Melki, Ronald ^{[8
,9
]}

Murayama, Shigeo ^{[10
,11
]}

Outeiro, Tiago F. ^{[12
,13
]}

Papa, Stella M. ^{[14
,15
]}

Stefanis, Leonidas ^{[16
,17
]}

Woerman, Amanda L. ^{[18
,19
]}

Surmeier, Dalton James ^{[20
,21
]}

Kalia, Lorraine V. ^{[5
,6
]}

Takahashi, Ryosuke ^{[22
]}

机构：

[1] Weill Cornell Med, Appel Inst Alzheimers Dis Res, New York, NY USA

[2] Weill Cornell Med, Brain & Mind Res Inst, New York, NY USA

[3] Univ Calif San Francisco, Sch Med, Dept Physiol & Neurol, San Francisco, CA USA

[4] Univ Sydney, Brain & Mind Ctr, Sch Med Sci, Camperdown, NSW, Australia

[5] Univ Hlth Network, Toronto Western Hosp, Krembil Res Inst, Edmond J Safra Program Parkinsons Dis, 399 Bathurst St, Toronto, ON, Canada

[6] Univ Toronto, Dept Med, Div Neurol, Toronto, ON, Canada

[7] Ecole Polytech Fed Lausanne EPFL, Brain Mind Inst, Lab Chem Biol Neurodegenerat, Lausanne, Switzerland

[8] CNRS, Inst Francois Jacob MIRCen, CEA, Fontenay Aux Roses, France

[9] CNRS, Lab Neurodegenerat Dis, Fontenay Aux Roses, France

[10] Tokyo Metropolitan Inst Geriatr & Gerontol, Dept Neuropathol, Tokyo, Japan

[11] Osaka Univ, United Grad Sch Child Dev, Brain Bank Neurodev Neurol & Psychiat Disorders, Osaka, Japan

[12] Univ Med Ctr, Dept Expt Neurodegenerat, Gottingen, Germany

[13] Newcastle Univ, Translat & Clin Res Inst, Fac Med Sci, Newcastle Upon Tyne, England

[14] Emory Univ, Sch Med, Dept Neurol, Atlanta, GA USA

[15] Emory Univ, Emory Natl Primate Res Ctr, Atlanta, GA USA

[16] Natl & Kapodistrian Univ Athens, Eginitio Hosp, Sch Med, Dept Neurol 1, Athens, Greece

[17] Acad Athens, Biomed Res Fdn, Athens, Greece

[18] Univ Massachusetts, Inst Appl Life Sci, Dept Biol, Amherst, MA USA

[19] Colorado State Univ, Prion Res Ctr, Dept Microbiol Immunol & Pathol, Ft Collins, CO USA

[20] Northwestern Univ, Feinberg Sch Med, Dept Neurosci, Chicago, IL USA

[21] Aligning Sci Parkinsons ASAP Collaborat Res Networ, Chevy Chase, MD USA

[22] Kyoto Univ, Grad Sch Med, Dept Neurol, Yoshida Konoe Cho,Sakyo Ku, Kyoto 6068501, Japan

来源：

MOVEMENT DISORDERS | 2024年 / 39卷 / 10期

关键词：

alpha-synuclein; Lewy pathology; neurodegeneration; pathogenesis; protein aggregation; INCIDENTAL LEWY BODY; HEPARAN-SULFATE PROTEOGLYCANS; MEMBRANE-BINDING; AMPLIFICATION ASSAYS; SYNAPTIC DYSFUNCTION; NIGROSTRIATAL SYSTEM; PREFORMED FIBRILS; GAMMA-SYNUCLEIN; UP-REGULATION; A-SYNUCLEIN;

D O I：

10.1002/mds.29897

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Various forms of Parkinson's disease, including its common sporadic form, are characterized by prominent alpha-synuclein (alpha Syn) aggregation in affected brain regions. However, the role of alpha Syn in the pathogenesis and evolution of the disease remains unclear, despite vast research efforts of more than a quarter century. A better understanding of the role of alpha Syn, either primary or secondary, is critical for developing disease-modifying therapies. Previous attempts to hone this research have been challenged by experimental limitations, but recent technological advances may facilitate progress. The Scientific Issues Committee of the International Parkinson and Movement Disorder Society (MDS) charged a panel of experts in the field to discuss current scientific priorities and identify research strategies with potential for a breakthrough. (c) 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

引用

页码：1663 / 1678

页数：16

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