Unfolded protein response in the COVID-19 context

被引：12
|
作者：
Barabutis, Nektarios [1 ]
机构：
[1] Univ Louisiana Monroe, Coll Pharm, Sch Basic Pharmaceut & Toxicol Sci, 1800 Bienville Dr, Monroe, LA 71201 USA
来源：
AGING AND HEALTH RESEARCH | 2021年 / 1卷 / 01期
关键词：
Inflammation; Acute lung injury; P53; Endothelium;
D O I：
10.1016/j.ahr.2020.100001
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
The unfolded protein response (UPR) maintains cellular homeostasis by regulating key elements of cellular growth and defense. Recent evidence suggests that this mechanism affects the vascular barrier function, by modulating lung endothelial permeability. Dysregulation of this barrier contributes in the irreversible outcomes of the SARS-CoV-2inflicted acute respiratory distress syndrome (ARDS). Thus, it is highly probable that the targeted activation of those UPR components in charge of repairing the destructed lung endothelium of the COVID-19 patients, may deliver a promising therapeutic possibility for those subjected to the devastating outcomes of the ongoing pandemic.
引用
收藏
页数：2
相关论文
共 50 条
  • [31] Thrombocytopenia is associated with a dysregulated host response in severe COVID-19
    Appelman, Brent
    Michels, Erik H. A.
    de Brabander, Justin
    Peters-Sengers, Hessel
    van Amstel, Rombout B. E.
    Noordzij, Sophie M.
    Klarenbeek, Augustijn M.
    van Linge, Christine C. A.
    Chouchane, Osoul
    Schuurman, Alex R.
    Reijnders, Tom D. Y.
    Douma, Renee A.
    Bos, Lieuwe D. J.
    Wiersinga, W. Joost
    van der Poll, Tom
    THROMBOSIS RESEARCH, 2023, 229 : 187 - 197
  • [32] COVID-19 is, in the end, an endothelial disease
    Libby, Peter
    Luscher, Thomas
    EUROPEAN HEART JOURNAL, 2020, 41 (32) : 3038 - 3044
  • [33] An outlook on potential protein targets of COVID-19 as a druggable site
    Noori, Rubia
    Sardar, Meryam
    MOLECULAR BIOLOGY REPORTS, 2022, 49 (11) : 10729 - 10748
  • [34] A male infant with COVID-19 in the context of ARPC1B deficiency
    Maria Castano-Jaramillo, Lina
    Antonio Yamazaki-Nakashimada, Marco
    Scheffler Mendoza, Selma Cecilia
    Carlos Bustamante-Ogando, Juan
    Elva Espinosa-Padilla, Sara
    Lugo Reyes, Saul O.
    PEDIATRIC ALLERGY AND IMMUNOLOGY, 2021, 32 (01) : 199 - 201
  • [35] Lutein activates downstream signaling pathways of unfolded protein response in hyperglycemic ARPE-19 cells
    Shivarudrappa, Arpitha Haranahalli
    Sharan, Kunal
    Ponesakki, Ganesan
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2022, 914
  • [36] Lessons learned from the mechanisms of posttraumatic inflammation extrapolated to the inflammatory response in COVID-19: a review
    Teuben, Michel P. J.
    Pfeifer, Roman
    Teuber, Henrik
    De Boer, Leonard L.
    Halvachizadeh, Sascha
    Shehu, Alba
    Pape, Hans-Christoph
    PATIENT SAFETY IN SURGERY, 2020, 14 (01)
  • [37] Management of Patients With Glomerulonephritis During the COVID-19 Pandemic: Recommendations From the Canadian Society of Nephrology COVID-19 Rapid Response Team
    Moran, Sarah M.
    Barbour, Sean
    Dipchand, Christine
    Garland, Jocelyn S.
    Hladunewich, Michelle
    Jauhal, Arenn
    Kappel, Joanne E.
    Levin, Adeera
    Pandeya, Sanjay
    Reich, Heather N.
    Thanabalasingam, Susan
    Thomas, Dorothy
    Ma, Jeffrey C.
    White, Christine
    CANADIAN JOURNAL OF KIDNEY HEALTH AND DISEASE, 2020, 7
  • [38] Unfolded protein response regulates P53 expression in the pulmonary endothelium
    Akhter, Mohammad S.
    Uddin, Mohammad A.
    Barabutis, Nektarios
    JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2019, 33 (10)
  • [39] The Unbearable Thrombus of COVID-19 Primary PCI, Thrombus, and COVID-19
    Dauerman, Harold L.
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2020, 76 (10) : 1177 - 1180
  • [40] Platelets and COVID-19
    Rohlfing, Anne-Katrin
    Rath, Dominik
    Geisler, Tobias
    Gawaz, Meinrad
    HAMOSTASEOLOGIE, 2021, 41 (05): : 379 - 385
12345