Unfolded protein response in the COVID-19 context

被引：12
|
作者：
Barabutis, Nektarios [1 ]
机构：
[1] Univ Louisiana Monroe, Coll Pharm, Sch Basic Pharmaceut & Toxicol Sci, 1800 Bienville Dr, Monroe, LA 71201 USA
来源：
AGING AND HEALTH RESEARCH | 2021年 / 1卷 / 01期
关键词：
Inflammation; Acute lung injury; P53; Endothelium;
D O I：
10.1016/j.ahr.2020.100001
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
The unfolded protein response (UPR) maintains cellular homeostasis by regulating key elements of cellular growth and defense. Recent evidence suggests that this mechanism affects the vascular barrier function, by modulating lung endothelial permeability. Dysregulation of this barrier contributes in the irreversible outcomes of the SARS-CoV-2inflicted acute respiratory distress syndrome (ARDS). Thus, it is highly probable that the targeted activation of those UPR components in charge of repairing the destructed lung endothelium of the COVID-19 patients, may deliver a promising therapeutic possibility for those subjected to the devastating outcomes of the ongoing pandemic.
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收藏
页数：2
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