Childhood-Onset Systemic Lupus Erythematosus

被引:0
|
作者
Sura, Anjali [1 ]
Failing, Christopher [2 ]
Co, Dominic O. [3 ]
Syverson, Grant [2 ]
机构
[1] SUNY Upstate Med Univ, Syracuse, NY 13210 USA
[2] Sanford Hlth, Fargo, ND USA
[3] Univ Wisconsin, Sch Med & Publ Hlth, Madison, WI USA
关键词
NEUROPSYCHIATRIC MANIFESTATIONS; CLINICAL-FEATURES; REVISED CRITERIA; MANAGEMENT; UPDATE; CLASSIFICATION; ASSOCIATION; ANTIBODY; SIMILARITIES; ANIFROLUMAB;
D O I
10.1542/pir.2023-006011
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Children make up almost 20% of all patients with systemic lupus erythematosus, with the most common age of presentation in adolescence. (3) (Based on moderate evidence: observational studies) • Children tend to have more organ damage, increased risk of mortality, and increased impact from immunosuppressive therapies. (2) (Based on moderate evidence: observational studies) • The symptoms of lupus can result from multiple defects in immune pathways, and this leads to many different phenotypes for the disease. (Based on moderate evidence: observational studies) • The variable mechanisms of pathogenesis result in a variability of responses to specific treatments and the need to individualize therapy to the patient’s clinical manifestations. (Based on moderate evidence: observational studies) • Belimumab is a new option available for childhood-onset systemic lupus erythematosus with or without renal disease. (60) (Based on moderate evidence: observational studies). © 2024 American Academy of Pediatrics. All rights reserved.
引用
收藏
页码:316 / 328
页数:13
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