Children born preterm or small for gestational age to mothers with multiple sclerosis: Do these children have an increased risk of infections in early life?

被引：0

作者：

Andersen, Mette Louise ^{[1
,2
,3
]}

Jolving, Line Riis ^{[1
,2
]}

Iachina, Maria ^{[1
,2
]}

Stenager, Egon ^{[4
,5
]}

Knudsen, Torben ^{[4
,6
]}

Norgard, Bente Mertz ^{[1
,2
]}

机构：

[1] Odense Univ Hosp, Ctr Clin Epidemiol, Klovervaenget 30,Entrance 216, DK-5000 Odense, Denmark

[2] Univ Southern Denmark, Dept Clin Res, Res Unit Clin Epidemiol, Odense, Denmark

[3] Univ Hosp Southern Jutland, Dept Gynecol & Obstet, Esbjerg, Denmark

[4] Univ Southern Denmark, Dept Reg Hlth Res, Odense, Denmark

[5] Univ Hosp Southern Jutland, Multiple Sclerosis Clin Southern Jutland, Aabenraa, Denmark

[6] Univ Hosp Southern Jutland, Dept Gastroenterol, Esbjerg, Denmark

来源：

MULTIPLE SCLEROSIS JOURNAL | 2024年 / 30卷 / 09期

关键词：

Multiple sclerosis; pregnancy; offspring; early-life infections; preterm; small for gestational age; BIRTH-WEIGHT; PREGNANCY; OUTCOMES; WOMEN; HOSPITALIZATION; ASSOCIATION; ADMISSIONS; MORBIDITY; DELIVERY; SYSTEM;

D O I：

10.1177/13524585241249077

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Mothers with multiple sclerosis are at increased risk of preterm birth and small for gestational age infants. Both conditions pose a risk of morbidity, including early-life infections.Objective: This study aimed to assess the risk of infections in the first 3 years of life among children born preterm or small for gestational age to mothers with multiple sclerosis.Methods: We used Danish national health registers to establish the study cohort of all births by women with MS born from 1995 to 2023. In Cox regression models, we estimated hazard ratios (HRs) of infections in preterm or small for gestational age children.Results: Preterm children had an adjusted HR of 1.49 (95% confidence interval (95% CI) 1.15-1.93) for hospital-diagnosed infection and 0.88 (95% CI 0.72-1.06) for antibiotic prescriptions. Small for gestational age children had an adjusted HR of 0.81 (95% CI 0.54-1.22) for hospital-diagnosed infection and 1.07 (95% CI 0.82-1.38) for antibiotic prescriptions.Conclusion: Children born preterm to mothers with multiple sclerosis had an increased risk of hospital-diagnosed infections in the first 3 years of life, but not of mild-to-moderate infections evaluated on prescriptions. Children born small for gestational age did not have an increased risk of infections.

引用

页码：1176 / 1184

页数：9

共 32 条

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