Multi-target Compounds against Trypanosomatid Parasites and Mycobacterium tuberculosis

被引：0
作者：
Gomes, Midiane Correia [1 ]
Padilha, Emanuelly Karla Araujo [1 ]
Angelo Diniz, Gustavo Rafael [1 ]
Gomes, Edilma Correia [1 ]
da Silva Santos-Junior, Paulo Fernando [1 ]
Zhan, Peng [2 ]
Ferreira da Siva-Junior, Edeildo [1 ]
机构：
[1] Univ Fed Alagoas, Inst Chem & Biotechnol, Res Grp Biol & Mol Chem, Campus AC Simoes, BR-57072970 Maceio, AL, Brazil
[2] Shandong Univ, Dept Med Chem, Sch Pharmaceut Sci, Key Lab Chem Biol,Minist Educ,Cheeloo Coll Med, 44 West Culture Rd, Jinan 250012, Shandong, Peoples R China
来源：
CURRENT DRUG TARGETS | 2024年 / 25卷 / 09期
关键词：
Multi-target compounds; trypanosoma; leishmaniasis; tuberculosis; neglected tropical diseases; monotherapy; IN-VITRO; DIHYDROFOLATE-REDUCTASE; LEISHMANIA-DONOVANI; DUAL INHIBITORS; DRUG TARGETS; DISEASE; BRUCEI; SINGLE; TRANSMISSION; FEXINIDAZOLE;
D O I：
10.2174/0113894501306843240606114854
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Multi-target drug treatment has become popular as a substitute for traditional monotherapy. Monotherapy can lead to resistance and side effects. Multi-target drug discovery is gaining importance as data on bioactivity becomes more abundant. The design of multi-target drugs is expected to be an important development in the pharmaceutical industry in the near future. This review presents multi-target compounds against trypanosomatid parasites (Trypanosoma cruzi, T. brucei, and Leishmania sp.) and tuberculosis (Mycobacterium tuberculosis), which mainly affect populations in socioeconomically unfavorable conditions. The article analyzes the studies, including their chemical structures, viral strains, and molecular docking studies, when available. The objective of this review is to establish a foundation for designing new multi-target inhibitors for these diseases.
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收藏
页码：602 / 619
页数：18
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