Metabolic dependencies of acute myeloid leukemia stem cells

被引：1

作者：

Shi, Xiangguo ^{[1
,2
]}

Feng, Mengdie ^{[1
]}

Nakada, Daisuke ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

[2] Penn State Univ, Coll Med, Dept Pediat, Div Pediat Hematol Oncol, Hershey, PA 16801 USA

来源：

INTERNATIONAL JOURNAL OF HEMATOLOGY | 2024年 / 120卷 / 04期

关键词：

Acute myeloid leukemia; Leukemia stem cell; Metabolic regulation; AMINO-ACID-METABOLISM; OXIDATIVE-PHOSPHORYLATION; SELF-RENEWAL; GLUCOSE-METABOLISM; INHIBITION; CHEMOTHERAPY; RESISTANCE; VENETOCLAX; THERAPY; NAMPT;

D O I：

10.1007/s12185-024-03789-x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy primarily driven by an immature population of AML cells termed leukemia stem cells (LSCs) that are implicated in AML development, chemoresistance, and relapse. An emerging area of research in AML focuses on identifying and targeting the aberrant metabolism in LSCs. Dysregulated metabolism is involved in sustaining functional properties of LSCs, impeding myeloid differentiation, and evading programmed cell death, both in the process of leukemogenesis and in response to chemotherapy. This review discusses recent discoveries regarding the aberrant metabolic processes of AML LSCs that have begun to change the therapeutic landscape of AML.

引用

页码：427 / 438

页数：12

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