Metabolic dependencies of acute myeloid leukemia stem cells

被引：1

作者：

Shi, Xiangguo ^{[1
,2
]}

Feng, Mengdie ^{[1
]}

Nakada, Daisuke ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

[2] Penn State Univ, Coll Med, Dept Pediat, Div Pediat Hematol Oncol, Hershey, PA 16801 USA

来源：

INTERNATIONAL JOURNAL OF HEMATOLOGY | 2024年 / 120卷 / 04期

关键词：

Acute myeloid leukemia; Leukemia stem cell; Metabolic regulation; AMINO-ACID-METABOLISM; OXIDATIVE-PHOSPHORYLATION; SELF-RENEWAL; GLUCOSE-METABOLISM; INHIBITION; CHEMOTHERAPY; RESISTANCE; VENETOCLAX; THERAPY; NAMPT;

D O I：

10.1007/s12185-024-03789-x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy primarily driven by an immature population of AML cells termed leukemia stem cells (LSCs) that are implicated in AML development, chemoresistance, and relapse. An emerging area of research in AML focuses on identifying and targeting the aberrant metabolism in LSCs. Dysregulated metabolism is involved in sustaining functional properties of LSCs, impeding myeloid differentiation, and evading programmed cell death, both in the process of leukemogenesis and in response to chemotherapy. This review discusses recent discoveries regarding the aberrant metabolic processes of AML LSCs that have begun to change the therapeutic landscape of AML.

引用

页码：427 / 438

页数：12

共 50 条

[41] Distinct Properties of Leukemia Stem Cells in Primary Refractory Acute Myeloid Leukemia
Mendler, Jason H.
Balys, Marlene
Sivagnanalingam, Umayal
Eberhardt, Allison
Thorne, Korinne
Ho, Tzu-Chieh
LaMere, Mark W.
Moore, Samuel
McMurray, Helene
Myers, Jason R.
Ashton, John M.
O'Dwyer, Kristen
Liesveld, Jane L.
Calvi, Laura M.
Becker, Michael W.
BLOOD, 2015, 126 (23)
[42] Metabolic Plasticity of Acute Myeloid Leukemia
Kreitz, Johanna
Schoenfeld, Christine
Seibert, Marcel
Stolp, Verena
Alshamleh, Islam
Oellerich, Thomas
Steffen, Bjoern
Schwalbe, Harald
Schnuetgen, Frank
Kurrle, Nina
Serve, Hubert
CELLS, 2019, 8 (08)
[43] EMBRYONIC STEM CELLS ANTIGEN (ESCA) EXPRESSION IN ACUTE MYELOID LEUKEMIA CELLS
Picot, T.
Aanei, C.
Fayard, A.
Tavernier-Tardy, E.
Flandrin-Gresta, P.
Tondeur, S.
Gouttenoire, M.
Wattel, E.
Guyotat, D.
Campos-Catafal, L.
HAEMATOLOGICA, 2016, 101 : 671 - 671
[44] Effect of Metabolic Reprogramming on the Biological Activity of Acute Myeloid Leukemia Cells
Liu, Tongyuan
Li, Dengju
Zhou, Jianfeng
BLOOD, 2018, 132
[45] Fatty Acid Desaturation Is a Metabolic Vulnerability of Acute Myeloid Leukemia Cells
Kanefsky, Joice
Jaspers, Yorrick
Martinez, Esteban
Huhn, Jacklyn
Di Marcoantonio, Daniela
Kemp, Stephan
Wiest, David
Sykes, Stephen M.
BLOOD, 2022, 140 : 5885 - 5886
[46] Leukemia Stem Cells in Chronic Myeloid Leukemia
Shan, Yi
DeSouza, Ngoc
Qiu, Qiang
Li, Shaoguang
LEUKEMIA STEM CELLS IN HEMATOLOGIC MALIGNANCIES, 2019, 1143 : 191 - 215
[47] Inhibition of Telomerase with Imetelstat Is Detrimental to Leukemia Stem Cells in Acute Myeloid Leukemia (AML)
Bruedigam, Claudia
Bagger, Frederik Otzen
Heidel, Florian H.
Kuhn, Catherine
Guignes, Solene
Song, Axia
Austin, Rebecca
Vu, Therese
Lee, Erwin M.
Moore, Andrew S.
Lock, Richard B.
Bullinger, Lars
Hill, Geoff R.
Lane, Steven W.
BLOOD, 2014, 124 (21)
[48] Tracing Leukemia Stem Cells and Their Influence on Clinical Course of Adult Acute Myeloid Leukemia
Kandeel, Eman Z.
El Sharkawy, Nahla
Hanafi, Marwa
Samra, Mohamed
Kamel, Azza
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2020, 20 (06): : 383 - 393
[49] Molecular mechanisms for stemness maintenance of acute myeloid leukemia stem cells
Wang, Jiazhen
Wang, Peipei
Zhang, Tiantian
Gao, Zhuying
Wang, Jing
Feng, Mengdie
Yin, Rong
Zhang, Haojian
BLOOD SCIENCE, 2019, 1 (01): : 77 - 83
[50] Acute Myeloid Leukemia Stem Cells: Origin, Characteristics, and Clinical Implications
Long, Nathaniel A.
Golla, Upendarrao
Sharma, Arati
Claxton, David F.
STEM CELL REVIEWS AND REPORTS, 2022, 18 (04) : 1211 - 1226

← 1 2 3 4 5 →