Marine Compounds and Age-Related Diseases: The Path from Pre-Clinical Research to Approved Drugs for the Treatment of Cardiovascular Diseases and Diabetes

被引：2
作者：
Giuliani, Maria Elisa [1 ,2 ]
Bigossi, Giorgia [1 ,2 ]
Lai, Giovanni [1 ,2 ]
Marcozzi, Serena [1 ,2 ]
Brunetti, Dario [3 ,4 ]
Malavolta, Marco [1 ,2 ]
机构：
[1] IRCCS INRCA, Adv Technol Ctr Aging Res, I-60121 Ancona, Italy
[2] IRCCS INRCA, Geriatr Mouse Clin, I-60121 Ancona, Italy
[3] Fdn IRCCS Ist Neurol Carlo Besta, Unit Med Genet & Neurogenet, I-20126 Milan, Italy
[4] Univ Milan, Dept Clin Sci & Community Hlth, Milan, Italy
来源：
MARINE DRUGS | 2024年 / 22卷 / 05期
关键词：
ageing; cardiovascular disease; type 2 diabetes mellitus; marine compounds; in vivo studies; clinical trials; OLIGOSACCHARIDES ATTENUATE HYPERTENSION; ALLEVIATES POSTPRANDIAL HYPERGLYCEMIA; ENZYME INHIBITORY PEPTIDES; ACTIVATED PROTEIN-KINASE; BUTYL-ISOBUTYL-PHTHALATE; ALPHA-AMYLASE INHIBITOR; CLAVA FLESH TISSUE; IN-VIVO; ECKLONIA-CAVA; INSULIN-RESISTANCE;
D O I：
10.3390/md22050210
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Ageing represents a main risk factor for several pathologies. Among them, cardiovascular diseases (CVD) and type 2 diabetes mellitus (T2DM) are predominant in the elderly population and often require prolonged use of multiple drugs due to their chronic nature and the high proportion of co-morbidities. Hence, research is constantly looking for novel, effective molecules to treat CVD and T2DM with minimal side effects. Marine active compounds, holding a great diversity of chemical structures and biological properties, represent interesting therapeutic candidates to treat these age-related diseases. This review summarizes the current state of research on marine compounds for the treatment of CVD and T2DM, from pre-clinical studies to clinical investigations and approved drugs, highlighting the potential of marine compounds in the development of new therapies, together with the limitations in translating pre-clinical results into human application.
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页数：22
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