1 College of Life Sciences, North China University of Science and Technology, 21 Bo Hai Road, Tangshan, P. R. China 2 3 4 6 Department of Biosciences, COMSATS University 45500, Islamabad Pakistan

被引：0

作者：

Yu, Yuan ^{[1
]}

Alkasir, Rashad ^{[2
]}

Farrukh, Anum ^{[3
]}

Riaz, Naveeda ^{[4
]}

Rasool, Aamir ^{[5
]}

Kaleem, Imdad ^{[6
]}

Khattak, Sahir Hameed ^{[7
]}

Bangash, Sajid Ali Khan ^{[8
]}

Khan, Muhammad Nauman ^{[9
,10
]}

Wahab, Sana ^{[11
]}

Ali, Baber ^{[11
]}

Kaplan, Alevcan ^{[12
]}

Almutairi, Saeedah Musaed ^{[13
]}

Alahmadi, Reham M. ^{[13
]}

Darwish, Doaa Bahaa Eldin ^{[14
]}

机构：

[1] North China Univ Sci & Technol, Coll Life Sci, 21 Bo Hai Rd, Tangshan, Peoples R China

[2] Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China

[3] Fauji Fdn Hosp FFH, Gen Med Dept, Rawalpindi, Pakistan

[4] Int Islamic Univ, Dept Biol Sci, Islamabad, Pakistan

[5] Univ Balochistan, Inst Biochem, Quetta 87300, Pakistan

[6] COMSATS Univ, Dept Biosci, Islamabad 45500, Pakistan

[7] Natl Agr Res Ctr, Natl Inst Genom & Adv Biotechnol NIGAB, Islamabad, Pakistan

[8] Univ Agr Peshawar, Inst Biotechnol & Genet Engn IBGE, Peshawar 25130, Pakistan

[9] Islamia Coll Peshawar, Dept Bot, Peshawar 25120, Pakistan

[10] Univ Peshawar, Univ Publ Sch, Biol Lab, Peshawar 25120, Pakistan

[11] Quaid i Azam Univ Islamabad, Dept Plant Sci, Islamabad 45320, Pakistan

[12] Batman Univ, Sason Vocat Sch, Dept Crop & Anim Prod, TR-72060 Batman, Turkiye

[13] King Saud Univ, Coll Sci, Dept Bot & Microbiol, PO 2455, Riyadh 11451, Saudi Arabia

[14] Mansoura Univ, Fac Sci, Bot Dept, Mansoura 35511, Egypt

来源：

POLISH JOURNAL OF ENVIRONMENTAL STUDIES | 2024年 / 33卷 / 05期

关键词：

Antibacterial Potential; MDR; Piperacillin-Tazobactam; ZnO-Nps; synergistic effect; ANTIBACTERIAL ACTIVITY; NANOPARTICLES; RESISTANCE; NANOTECHNOLOGY;

D O I：

暂无

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Nanotechnology offers exciting prospects against infectious agents, particularly multidrug resistance bacteria (MDR), which is the roaring concern of this era. Zinc oxide nanoparticles (ZnO-Nps) efficiently deliver therapeutic agents into living systems due to their biocompatibility and bioactivity, which make them highly effective against infectious pathogens. The present investigation was designed to investigate the impact of the ZnO-Nps in combination with the Piperacillin-Tazobactam (TZP) drug against MDR. TZP are beta-lactam antibiotics highly effective against Gram-positive and Gram-negative bacteria such as Pseudomonas aeruginosa , and are recommended for the empirical treatment of Febrile neutropenia (FN) associated with chemotherapy treatment. For this study, three different -sized ZnONp combinations were used. The extended -spectrum beta-lactamase (ESBLs) producing Escheria coli and MDR P. aeruginosa strain sensitivity profiling towards different combinations of ZnO-Np s and Piperacillin-Tazobactam were measured. The synthesized Zno-Np s were designated as Zn-1, Zn2, and Zn-3 based on their sizes, and were made in different combinations with the commercially available drug TZP (ZnO-Np s + Drug) against MDR E . coli and P. aeruginosa . There was no synergistic effect observed against growth inhibition of E.coli . The combined dose of Zn-1 and TZP showed better antibacterial efficacy even as compared to the pure drug against P. aeruginosa . The study revealed that the dosage and biological activity of drugs used to treat fatal human diseases like cancer can be decreased while their efficacy can be boosted by using ZnO nanoparticles as powerful drug delivery systems.

引用

页码：4893 / 4902

页数：10