Risk factors for cardiovascular disease mortality in patients with myelodysplastic syndromes: A nationwide, registry-based cohort study

被引：3

作者：

Liapis, Konstantinos ^{[1
,13
]}

Vrachiolias, Georgios ^{[1
]}

Papadopoulos, Vasileios ^{[1
]}

Kourakli, Alexandra ^{[2
]}

Galanopoulos, Athanasios G. ^{[3
]}

Papoutselis, Menelaos ^{[1
]}

Papageorgiou, Sotirios G. ^{[4
]}

Diamantopoulos, Panagiotis T. ^{[5
]}

Pappa, Vassiliki ^{[4
]}

Viniou, Nora-Athina ^{[5
]}

Vassilakopoulos, Theodoros P. ^{[6
]}

Hatzimichael, Eleftheria ^{[7
]}

Bouronikou, Eleni ^{[8
]}

Ximeri, Maria ^{[9
]}

Pontikoglou, Charalambos ^{[9
]}

Panayiotidis, Panayiotis ^{[10
]}

Karakatsanis, Stamatis ^{[11
]}

Vardi, Anna ^{[12
]}

Symeonidis, Argiris ^{[2
]}

Kotsianidis, Ioannis ^{[1
]}

机构：

[1] Democritus Univ Thrace, Med Sch, Dept Hematol, Alexandroupolis, Greece

[2] Univ Hosp Patras, Dept Internal Med, Rion, Greece

[3] Georgios Gennimatas Hosp, Dept Clin Haematol, Athens, Greece

[4] Attikon Univ, Gen Hosp, Dept Internal Med 2, Athens, Greece

[5] Natl & Kapodistrian Univ Athens, Dept Internal Med 1, Athens, Greece

[6] Natl & Kapodistrian Univ Athens, Laikon Gen Hosp, Dept Haematol, Athens, Greece

[7] Univ Hosp Ioannina, Dept Hematol, Ioannina, Greece

[8] Univ Hosp Larissa, Dept Hematol, Larisa, Greece

[9] Univ Gen Hosp Heraklion, Dept Hematol, Iraklion, Greece

[10] Natl & Kapodistrian Univ Athens, Propaedeut Dept Internal Med 1, Athens, Greece

[11] Sotiria Gen Hosp, Dept Hematol, Athens, Greece

[12] Georgios Papanicolaou Gen Hosp, Dept Hematol & Stem Cell Transplantat, Thessaloniki, Greece

[13] Democritus Univ Thrace, Univ Hosp Alexandroupolis, Dept Hematol, Dragana Area, Alexandroupolis 68100, Greece

来源：

EJHAEM | 2020年 / 1卷 / 01期

关键词：

cardiovascular disease; coronary heart disease; death; erythropoiesis-stimulating agents; mortality; myelodysplastic syndromes; CLONAL HEMATOPOIESIS;

D O I：

10.1002/jha2.30

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cardiovascular disease (CVD) emerges as a major cause of death in patients with myelodysplastic syndrome (MDS), but predictors of fatal CVD and the effect of MDS-specific treatments on CVD mortality remain largely unknown. In an analysis involving 831 patients with MDS with known causes of death, we noted an independent association of lower risk MDS, age >70 years, pre-existing CVD, and treatment with erythropoiesis-stimulating agents with a higher risk of death from CVD. If externally validated, these simple risk factors could increase clinicians' awareness toward CVD complications and guide early introduction of intensive monitoring and preventive interventions in MDS patients.

引用

页码：255 / 261

页数：7

共 14 条

[1] Recombinant human erythropoietins and cancer patients: Updated meta-analysis of 57 studies including 9353 patients [J].

Bohlius, Julia ;

Wilson, Jayne ;

Seidenfeld, Jerome ;

Piper, Margaret ;

Schwarzer, Guido ;

Sandercock, Josie ;

Trelle, Sven ;

Weingart, Olaf ;

Bayliss, Sue ;

Djulbegovic, Benjamin ;

Bennett, Charles L. ;

Langensiepen, Simon ;

Hyde, Chris ;

Engert, Andreas .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2006, 98 (10) :708-714

[2] Risk and timing of cardiovascular death among patients with myelodysplastic syndromes [J].

Brunner, Andrew M. ;

Blonquist, Traci M. ;

Hobbs, Gabriela S. ;

Amrein, Philip C. ;

Neuberg, Donna S. ;

Steensma, David P. ;

Abel, Gregory A. ;

Fathi, Amir T. .

BLOOD ADVANCES, 2017, 1 (23) :2032-2040

[3] Cardiac and genetic predictors of cardiovascular risk in patients with myelodysplastic syndromes [J].

Chen, Evan C. ;

Werner, Lillian ;

Hobbs, Gabriela S. ;

Narayan, Rupa ;

Amrein, Philip C. ;

Fathi, Amir T. ;

Brunner, Andrew M. .

LEUKEMIA & LYMPHOMA, 2019, 60 (12) :3058-3062

[4] Clinical application and proposal for modification of the International Working Group (IWG) response criteria in myelodysplasia [J].

Cheson, Bruce D. ;

Greenberg, Peter L. ;

Bennett, John M. ;

Lowenberg, Bob ;

Wijermans, Pierre W. ;

Nimer, Stephen D. ;

Pinto, Antonio ;

Beran, Miloslav ;

de Witte, Theo M. ;

Stone, Richard M. ;

Mittelman, Moshe ;

Sanz, Guillermo F. ;

Gore, Steven D. ;

Schiffer, Charles A. ;

Kantarjian, Hagop .

BLOOD, 2006, 108 (02) :419-425

[5] Risk stratification based on both disease status and extra-hematologic comorbidities in patients with myelodysplastic syndrome [J].

Della Porta, Matteo G. ;

Malcovati, Luca ;

Strupp, Corinna ;

Ambaglio, Ilaria ;

Kuendgen, Andrea ;

Zipperer, Esther ;

Travaglino, Erica ;

Invernizzi, Rosangela ;

Pascutto, Cristiana ;

Lazzarino, Mario ;

Germing, Ulrich ;

Cazzola, Mario .

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2011, 96 (03) :441-449

[6] Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice [J].

Fuster, Jose J. ;

MacLauchlan, Susan ;

Zuriaga, Maria A. ;

Polackal, Maya N. ;

Ostriker, Allison C. ;

Chakraborty, Raja ;

Wu, Chia-Ling ;

Sano, Soichi ;

Muralidharan, Sujatha ;

Rius, Cristina ;

Vuong, Jacqueline ;

Jacob, Sophia ;

Muralidhar, Varsha ;

Robertson, Avril A. B. ;

Cooper, Matthew A. ;

Andres, Vicente ;

Hirschi, Karen K. ;

Martin, Kathleen A. ;

Walsh, Kenneth .

SCIENCE, 2017, 355 (6327) :842-847

[7] Myelodysplastic syndromes and the risk of cardiovascular disease in older adults: A SEER-medicare analysis [J].

Herrera, Diego Adrianzen ;

Pradhan, Kith ;

Snyder, Rose ;

Karanth, Siddharth ;

Janakiram, Murali ;

Mantzaris, Ioannis ;

Braunschweig, Ira ;

Budhathoki, Anjali ;

Shah, Urvi A. ;

Verma, Amit K. ;

Murthy, Santosh B. ;

Shastri, Aditi .

LEUKEMIA, 2020, 34 (06) :1689-1693

[8] Erythropoiesis-stimulating agents and cardiovascular events in patients with myelodysplastic syndrome and multiple myeloma [J].

Horvath-Puho, Erzsebet ;

Suttorp, Marit M. ;

Frederiksen, Henrik ;

Hoekstra, Tiny ;

Dekkers, Olaf M. ;

Pedersen, Lars ;

Cannegieter, Suzanne C. ;

Dekker, Friedo W. ;

Sorensen, Henrik Toft .

CLINICAL EPIDEMIOLOGY, 2018, 10 :1371-1380

[9] Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease [J].

Jaiswal, S. ;

Natarajan, P. ;

Silver, A. J. ;

Gibson, C. J. ;

Bick, A. G. ;

Shvartz, E. ;

McConkey, M. ;

Gupta, N. ;

Gabriel, S. ;

Ardissino, D. ;

Baber, U. ;

Mehran, R. ;

Fuster, V. ;

Danesh, J. ;

Frossard, P. ;

Saleheen, D. ;

Melander, O. ;

Sukhova, G. K. ;

Neuberg, D. ;

Libby, P. ;

Kathiresan, S. ;

Ebert, B. L. .

NEW ENGLAND JOURNAL OF MEDICINE, 2017, 377 (02) :111-121

[10] Shared Risk Factors in Cardiovascular Disease and Cancer [J].

Koene, Ryan J. ;

Prizment, Anna E. ;

Blaes, Anne ;

Konety, Suma H. .

CIRCULATION, 2016, 133 (11) :1104-1114

← 1 2 →