Improvement of Post-Surgery Constipation in Patients with Fractures by Lactobacillus rhamnosus JYLR-127: A Single-Blind Randomized Controlled Trial

被引:4
作者
Han, Yiyang [1 ,2 ]
Zhou, Yunlong [3 ]
Xu, Xuan [4 ]
Chen, Shen [2 ]
Zhang, Shuwei [2 ]
Jiang, Nan [2 ]
Liu, Zhiqiang [3 ]
Zhang, Junyu [3 ]
Luo, Zhaowei [4 ]
Zhang, Xinfeng [5 ]
Hao, Liang [1 ]
Chen, Tingtao [1 ,4 ,5 ]
机构
[1] Nanchang Univ, Affiliated Hosp 2, Jiangxi Med Coll, Dept Orthoped, Nanchang 330006, Peoples R China
[2] Nanchang Univ, Jiangxi Med Coll, Queen Mary Sch, Nanchang 330031, Peoples R China
[3] Leshan Peoples Hosp, Dept Orthoped, Leshan 614003, Peoples R China
[4] Nanchang Univ, Inst Translat Med, Jiangxi Med Coll, Nanchang 330031, Peoples R China
[5] Nanchang Univ, Jiangxi Med Coll, Sch Pharm, Nanchang 330031, Peoples R China
关键词
constipation after fracture surgery; probiotic preparation; Lactobacillus rhamnosus; adjuvant therapy; gut microbiota; FUNCTIONAL CONSTIPATION; PREVALENCE; PROBIOTICS;
D O I
10.3390/nu16101505
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The high prevalence of constipation after fracture surgery brings intolerable discomfort to patients on the one hand, and affects post-surgery nutrient absorption on the other hand, resulting in poor prognosis. Given the acknowledged probiotic properties of Lactobacillus rhamnosus, 100 fracture patients with post-surgery constipation were centrally enrolled and administered orally with L. rhamnosus JYLR-127 to assess the efficacy of probiotic-adjuvant therapy in alleviating post-fracture constipation symptoms. The results showed that L. rhamnosus JYLR-127 improved fecal properties, promoted gastrointestinal recovery, and relieved constipation symptoms, which were mainly achieved by elevating Firmicutes (p < 0.01) and descending Bacteroidetes (p < 0.001), hence remodeling the disrupted intestinal microecology. In addition, blood routine presented a decrease in C-reactive protein levels (p < 0.05) and an increase in platelet counts (p < 0.05) after probiotic supplementation, prompting the feasibility of L. rhamnosus JYLR-127 in anti-inflammation, anti-infection and hemorrhagic tendency prevention after fracture surgery. Our study to apply probiotics in ameliorating constipation after fracture surgery is expected to bless the bothered patients, and provide broader application scenarios for L. rhamnosus preparations.
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页数:14
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