Role of immunometabolism during congenital cytomegalovirus infection

被引：0
作者：
Zwezdaryk, Kevin J. [1 ,2 ,3 ]
Kaur, Amitinder [1 ,4 ]
机构：
[1] Tulane Univ, Sch Med, Dept Microbiol & Immunol, New Orleans, LA 70118 USA
[2] Tulane Univ, Sch Med, Tulane Ctr Aging, New Orleans, LA 70112 USA
[3] Tulane Univ, Sch Med, Tulane Brain Inst, New Orleans, LA 70112 USA
[4] Tulane Natl Primate Res Ctr, Div Immunol, Covington, LA USA
来源：
IMMUNOMETABOLISM | 2023年 / 5卷 / 04期
关键词：
placenta; immunometabolism; congenital cytomegalovirus; T-CELLS; GLUCOSE; GLYCOLYSIS; ACTIVATION; DISEASE;
D O I：
10.1097/IN9.0000000000000034
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Cytomegalovirus (CMV) is a master manipulator of host metabolic pathways. The impact of CMV metabolic rewiring during congenital CMV on immune function is unknown. CMV infection can directly alter glycolytic and oxidative phosphorylation pathways in infected cells. Recent data suggests CMV may alter metabolism in uninfected neighboring cells. In this mini review, we discuss how CMV infection may impact immune function through metabolic pathways. We discuss how immune cells differ between maternal and decidual compartments and how altered immunometabolism may contribute to congenital infections.
引用
收藏
页数：4
相关论文
共 32 条
[21]   Glucose Transporter 1-Expressing Proinflammatory Monocytes Are Elevated in Combination Antiretroviral Therapy-Treated and Untreated HIV+ Subjects [J].
Palmer, Clovis S. ;
Anzinger, Joshua J. ;
Zhou, Jingling ;
Gouillou, Maelenn ;
Landay, Alan ;
Jaworowski, Anthony ;
McCune, Joseph M. ;
Crowe, Suzanne M. .
JOURNAL OF IMMUNOLOGY, 2014, 193 (11) :5595-5603
[22]   Increased glucose metabolic activity is associated with CD4 R T-cell activation and depletion during chronic HIV infection [J].
Palmer, Clovis S. ;
Ostrowski, Matias ;
Gouillou, Maelenn ;
Tsai, Louis ;
Yu, Di ;
Zhou, Jingling ;
Henstridge, Darren C. ;
Maisa, Anna ;
Hearps, Anna C. ;
Lewin, Sharon R. ;
Landay, Alan ;
Jaworowski, Anthony ;
McCune, Joseph M. ;
Crowe, Suzanne M. .
AIDS, 2014, 28 (03) :297-309
[23]   Valganciclovir Is Beneficial in Children with Congenital Cytomegalovirus and Isolated Hearing Loss [J].
Pasternak, Yehonatan ;
Ziv, Liron ;
Attias, Joseph ;
Amir, Jacob ;
Bilaysky, Efraim .
JOURNAL OF PEDIATRICS, 2018, 199 :166-170
[24]  
Pearce Erika L, 2013, Science, V342, P1242454, DOI 10.1126/science.1242454
[25]   Role of Free Radical Formation in Murine Cytomegalovirus-Induced Hearing Loss [J].
Pecha, Phayvanh P. ;
Almishaal, Ali A. ;
Mathur, Pranav D. ;
Hillas, Elaine ;
Johnson, Taelor ;
Price, Melissa S. ;
Haller, Travis ;
Yang, Jun ;
Rajasekaran, Namakkal S. ;
Firpo, Matthew A. ;
Park, Albert H. .
OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 2020, 162 (05) :709-717
[26]   Cytomegalovirus: Shape-Shifting the Immune System [J].
Picarda, Gaelle ;
Benedict, Chris A. .
JOURNAL OF IMMUNOLOGY, 2018, 200 (12) :3881-3889
[27]   Intercellular communication within the virus microenvironment affects the susceptibility of cells to secondary viral infections [J].
Song, Bokai ;
Sheng, Xinlei ;
Justice, Joshua L. ;
Lum, Krystal K. ;
Metzger, Peter J. ;
Cook, Katelyn C. ;
Kostas, James C. ;
Cristea, Ileana M. .
SCIENCE ADVANCES, 2023, 9 (19)
[28]  
Suarez D., 2023, Laryngoscope
[29]   Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy [J].
Swamy, Mahima ;
Pathak, Shalini ;
Grzes, Katarzyna M. ;
Damerow, Sebastian ;
Sinclair, Linda V. ;
van Aalten, Daan M. F. ;
Cantrell, Doreen A. .
NATURE IMMUNOLOGY, 2016, 17 (06) :712-+
[30]   CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability [J].
van der Windt, Gerritje J. W. ;
O'Sullivan, David ;
Everts, Bart ;
Huang, Stanley Ching-Cheng ;
Buck, Michael D. ;
Curtis, Jonathan D. ;
Chang, Chih-Hao ;
Smith, Amber M. ;
Ai, Teresa ;
Faubert, Brandon ;
Jones, Russell G. ;
Pearce, Edward J. ;
Pearce, Erika L. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (35) :14336-14341
1234