Role of immunometabolism during congenital cytomegalovirus infection

被引：0
作者：
Zwezdaryk, Kevin J. [1 ,2 ,3 ]
Kaur, Amitinder [1 ,4 ]
机构：
[1] Tulane Univ, Sch Med, Dept Microbiol & Immunol, New Orleans, LA 70118 USA
[2] Tulane Univ, Sch Med, Tulane Ctr Aging, New Orleans, LA 70112 USA
[3] Tulane Univ, Sch Med, Tulane Brain Inst, New Orleans, LA 70112 USA
[4] Tulane Natl Primate Res Ctr, Div Immunol, Covington, LA USA
来源：
IMMUNOMETABOLISM | 2023年 / 5卷 / 04期
关键词：
placenta; immunometabolism; congenital cytomegalovirus; T-CELLS; GLUCOSE; GLYCOLYSIS; ACTIVATION; DISEASE;
D O I：
10.1097/IN9.0000000000000034
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Cytomegalovirus (CMV) is a master manipulator of host metabolic pathways. The impact of CMV metabolic rewiring during congenital CMV on immune function is unknown. CMV infection can directly alter glycolytic and oxidative phosphorylation pathways in infected cells. Recent data suggests CMV may alter metabolism in uninfected neighboring cells. In this mini review, we discuss how CMV infection may impact immune function through metabolic pathways. We discuss how immune cells differ between maternal and decidual compartments and how altered immunometabolism may contribute to congenital infections.
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页数：4
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