The Multifaceted Role of Alpha-Lipoic Acid in Cancer Prevention, Occurrence, and Treatment

被引：10
作者：
Yan, Shuai [1 ]
Lu, Jiajie [1 ]
Chen, Bingqing [1 ]
Yuan, Liuxia [2 ]
Chen, Lin [2 ]
Ju, Linglin [2 ]
Cai, Weihua [3 ]
Wu, Jinzhu [1 ,3 ]
机构：
[1] Nantong Univ, Med Sch, Nantong 226300, Peoples R China
[2] Nantong Univ, Affiliated Nantong Hosp 3, Inst Liver Dis, Nantong 226300, Peoples R China
[3] Nantong Univ, Affiliated Nantong Hosp 3, Dept Hepatobiliary Surg, Nantong 226300, Peoples R China
来源：
ANTIOXIDANTS | 2024年 / 13卷 / 08期
关键词：
alpha-lipoic acid; cancer; antioxidants; reactive oxygen species; oxidative stress; nanomedicine; EPITHELIAL-MESENCHYMAL TRANSITION; MEMBRANE-PERMEABILITY TRANSITION; NEUTROPHIL EXTRACELLULAR TRAPS; INDUCED PERIPHERAL NEUROPATHY; OXIDATIVE STRESS; EXCISION-REPAIR; CHEMOTHERAPEUTIC-AGENTS; INSULIN SENSITIVITY; INDUCED APOPTOSIS; CELL-DEATH;
D O I：
10.3390/antiox13080897
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Alpha-lipoic acid (ALA) is a naturally occurring compound synthesized by mitochondria and widely distributed in both animal and plant tissues. It primarily influences cellular metabolism and oxidative stress networks through its antioxidant properties and is an important drug for treating metabolic diseases associated with oxidative damage. Nevertheless, research indicates that the mechanism by which ALA affects cancer cells is distinct from that observed in normal cells, exhibiting pro-oxidative properties. Therefore, this review aims to describe the main chemical and biological functions of ALA in the cancer environment, including its mechanisms and effects in tumor prevention and anticancer activity, as well as its role as an adjunctive drug in cancer therapy. We specifically focus on the interactions between ALA and various carcinogenic and anti-carcinogenic pathways and discuss ALA's pro-oxidative capabilities in the unique redox environment of cancer cells. Additionally, we elaborate on ALA's roles in nanomedicine, hypoxia-inducible factors, and cancer stem cell research, proposing hypotheses and potential explanations for currently unresolved issues.
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页数：22
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共 174 条
[31]   Diabetic Nephropathy: Significance of Determining Oxidative Stress and Opportunities for Antioxidant Therapies [J].
Darenskaya, Marina ;
Kolesnikov, Sergey ;
Semenova, Natalya ;
Kolesnikova, Lyubov .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (15)
[32]   The Role of Reactive Oxygen Species (ROS) in the Biological Activities of Metallic Nanoparticles [J].
Dayem, Ahmed Abdal ;
Hossain, Mohammed Kawser ;
Lee, Soo Bin ;
Kim, Kyeongseok ;
Saha, Subbroto Kumar ;
Yang, Gwang-Mo ;
Choi, Hye Yeon ;
Cho, Ssang-Goo .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (01)
[33]   Monitoring of copper, arsenic and antimony levels in agricultural soils impacted and non-impacted by mining activities, from three regions in Chile [J].
De Gregori, I ;
Fuentes, E ;
Rojas, M ;
Pinochet, H ;
Potin-Gautier, M .
JOURNAL OF ENVIRONMENTAL MONITORING, 2003, 5 (02) :287-295
[34]   Global burden of cancer attributable to infections in 2018: a worldwide incidence analysis [J].
de Martel, Catherine ;
Georges, Damien ;
Bray, Freddie ;
Ferlay, Jacques ;
Clifford, Gary M. .
LANCET GLOBAL HEALTH, 2020, 8 (02) :E180-E190
[35]   Role of ROS and RNS Sources in Physiological and Pathological Conditions [J].
Di Meo, Sergio ;
Reed, Tanea T. ;
Venditti, Paola ;
Manuel Victor, Victor .
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2016, 2016
[36]   The disulfide compound α-lipoic acid and its derivatives: A novel class of anticancer agents targeting mitochondria [J].
Doersam, Bastian ;
Fahrer, Joerg .
CANCER LETTERS, 2016, 371 (01) :12-19
[37]   Exercise-induced brachial artery vasodilation: effects of antioxidants and exercise training in elderly men [J].
Donato, Anthony J. ;
Uberoi, Abhimanyu ;
Bailey, Damian M. ;
Wray, D. Walter ;
Richardson, Russell S. .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2010, 298 (02) :H671-H678
[38]   Therapeutic Potential of Alpha-Lipoic Acid in Viral Infections, including COVID-19 [J].
Dragomanova, Stela ;
Miteva, Simona ;
Nicoletti, Ferdinando ;
Mangano, Katia ;
Fagone, Paolo ;
Pricoco, Salvatore ;
Staykov, Hristian ;
Tancheva, Lyubka .
ANTIOXIDANTS, 2021, 10 (08)
[39]   Arsenicals affect base excision repair by several mechanisms [J].
Ebert, Franziska ;
Weiss, Andre ;
Bueltemeyer, Milena ;
Hamann, Ingrit ;
Hartwig, Andrea ;
Schwerdtle, Tanja .
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2011, 715 (1-2) :32-41
[40]   Emerging Roles of C-Myc in Cancer Stem Cell-Related Signaling and Resistance to Cancer Chemotherapy: A Potential Therapeutic Target Against Colorectal Cancer [J].
Elbadawy, Mohamed ;
Usui, Tatsuya ;
Yamawaki, Hideyuki ;
Sasaki, Kazuaki .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (09)
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