Application of Antioxidant Compounds in Bone Defect Repair

被引：9

作者：

Wang, Jiajia ^{[1
,2
,3
]}

Zhang, Yubing ^{[1
,2
,3
]}

Tang, Qingming ^{[1
,2
,3
]}

Zhang, Yinan ^{[4
]}

Yin, Ying ^{[1
,2
,3
]}

Chen, Lili ^{[1
,2
,3
]}

机构：

[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Stomatol, Wuhan 430022, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Stomatol, Wuhan 430030, Peoples R China

[3] Hubei Prov Key Lab Oral & Maxillofacial Dev & Rege, Wuhan 430022, Peoples R China

[4] Tongji Univ, Sch Chem Sci & Engn, Shanghai 200092, Peoples R China

来源：

ANTIOXIDANTS | 2024年 / 13卷 / 07期

基金：

中国国家自然科学基金;

关键词：

bone defect; antioxidant compounds; biomaterials; ROS; NITRIC-OXIDE SYNTHASE; REACTIVE OXYGEN; OXIDATIVE STRESS; N-ACETYLCYSTEINE; OSTEOBLASTIC DIFFERENTIATION; OSTEOCLAST DIFFERENTIATION; DELIVERY-SYSTEM; LIPOIC ACID; OSTEOGENESIS; ICARIIN;

D O I：

10.3390/antiox13070789

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bone defects caused by trauma, tumor resection, and infections are significant clinical challenges. Excessive reactive oxygen species (ROS) usually accumulate in the defect area, which may impair the function of cells involved in bone formation, posing a serious challenge for bone repair. Due to the potent ROS scavenging ability, as well as potential anti-inflammatory and immunomodulatory activities, antioxidants play an indispensable role in the maintenance and protection of bone health and have gained increasing attention in recent years. This narrative review aims to give an overview of the main research directions on the application of antioxidant compounds in bone defect repair over the past decade. In addition, the positive effects of various antioxidants and their biomaterial delivery systems in bone repair are summarized to provide new insights for exploring antioxidant-based strategies for bone defect repair.

引用

页数：24

共 170 条

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