Enhancing signal-to-noise ratio in stimulated Brillouin microscopy with low duty cycle nanosecond pulses

被引：0
|
作者：
Chow, Desmond M. [1 ,2 ]
Yun, Seok-Hyun [1 ,2 ,3 ]
机构：
[1] Harvard Med Sch, Boston, MA 02114 USA
[2] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA
[3] MIT, Harvard MIT Hlth Sci & Technol, Cambridge, MA 02139 USA
来源：
LABEL-FREE BIOMEDICAL IMAGING AND SENSING, LBIS 2024 | 2024年 / 12854卷
关键词：
Brillouin scattering; elastography; nonlinear optics;
D O I：
10.1117/12.2692239
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Stimulated Brillouin scattering (SBS) is a valuable technique for studying the mechanical properties of biological samples. We propose a novel scheme utilizing low duty cycle, nanosecond pulses for pump and probe beams. Our approach achieves higher signal-to-noise (SNR) than SBS microscopy and continuous-wave Brillouin microscopy, even with reduced average power exposure. Experimental results demonstrate a shot noise-limited SNR exceeding 1000 with precise mapping of cellular features. The interlaced boxcar method effectively retrieves the SBS signal, while optimizing pulse width and peak power further enhances optical power efficiency. This pulse scheme offers improved precision and reduced laser power exposure compared to spontaneous Brillouin and continuous wave (cw) SBS approaches.
引用
收藏
页数：3
相关论文
共 50 条
  • [31] A radar echo signal detection algorithm in low signal-to-noise ratio
    Li, Xiangju
    PROCEEDINGS OF THE 2016 3RD INTERNATIONAL CONFERENCE ON MATERIALS ENGINEERING, MANUFACTURING TECHNOLOGY AND CONTROL, 2016, 67 : 349 - 353
  • [32] Enhancing the signal-to-noise ratio of an infrared photodetector with a circular metal grating
    Bhat, Ravi D. R.
    Panoiu, Nicolae C.
    Brueck, Steven R. J.
    Osgood, Richard M., Jr.
    OPTICS EXPRESS, 2008, 16 (07) : 4588 - 4596
  • [33] Enhancing the signal-to-noise ratio of ICA-based extracted ERPs
    Lemm, S
    Curio, G
    Hlushchuk, Y
    Müller, KR
    IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 2006, 53 (04) : 601 - 607
  • [34] Uncoupled multi-core fiber enhancing signal-to-noise ratio
    Hayashi, Tetsuya
    Taru, Toshiki
    Shimakawa, Osamu
    Sasaki, Takashi
    Sasaoka, Eisuke
    OPTICS EXPRESS, 2012, 20 (26): : B94 - B103
  • [35] Optimization of polarizer azimuth in improving signal-to-noise ratio in Kerr microscopy
    Wang, X.
    Lian, J.
    Xu, X. J.
    Li, X.
    Li, P.
    Li, M. M.
    Wang, Y.
    Liu, Y. X.
    APPLIED OPTICS, 2016, 55 (07) : 1725 - 1730
  • [36] Improvement of signal-to-noise ratio in photothermal microscopy by optimizing detection aperture
    Miyazaki, Jun
    OPTICS COMMUNICATIONS, 2017, 390 : 99 - 104
  • [37] Noise Analysis and Signal-to-Noise Ratio Enhancement of Fiber-Based Photoacoustic Microscopy
    Huang Jie
    Liang Yizhi
    Zhong Xiaoxuan
    Jin Long
    Guan Baiou
    CHINESE JOURNAL OF LASERS-ZHONGGUO JIGUANG, 2022, 49 (15):
  • [38] Multiwavelength Coherent Brillouin Random Fiber Laser With Ultrahigh Optical Signal-to-Noise Ratio
    Zhang, Liang
    Xu, Yanping
    Gao, Song
    Saxena, Bhavaye
    Chen, Liang
    Bao, Xiaoyi
    IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS, 2018, 24 (03)
  • [39] Signal-to-noise ratio improvement in Brillouin optical correlation domain analysis combining Brillouin gain and loss effects
    Jin, Chongjiu
    Zou, Weiwen
    Chen, Jianping
    22ND INTERNATIONAL CONFERENCE ON OPTICAL FIBER SENSORS, PTS 1-3, 2012, 8421
  • [40] An approach to formant frequency estimation at low signal-to-noise ratio
    Fattah, S. A.
    Zhu, W. -P.
    Ahmad, M. O.
    2007 IEEE INTERNATIONAL CONFERENCE ON ACOUSTICS, SPEECH, AND SIGNAL PROCESSING, VOL IV, PTS 1-3, 2007, : 469 - +
12345