Development and characterization of Polycaprolactone/chitosan-based scaffolds for tissue engineering of various organs: A review

被引：21

作者：

Esmaeili, Javad ^{[1
,2
,3
]}

Jalise, Saeedeh Zare ^{[4
]}

Pisani, Silvia ^{[5
]}

Rochefort, Gael Y. ^{[6
,7
]}

Ghobadinezhad, Farbod ^{[8
]}

Mirzaei, Zeynab ^{[9
]}

Mohammed, Riaz Ur Rehman ^{[10
]}

Fathi, Mehdi ^{[11
]}

Tebyani, Amir ^{[12
]}

Nejad, Zohreh Mousavi ^{[13
,14
]}

机构：

[1] Arak Univ, Fac Engn, Dept Chem Engn, Arak 3815688349, Iran

[2] TISSUEHUB Co, Dept Tissue Engn, Tehran, Iran

[3] Universal Sci Educ & Res Network USERN, Tissue Engn Hub TEHUB, Tehran, Iran

[4] Qom Univ Med Sci, Sch Med, Dept Tissue Engn & Appl Cell Sci, Qom, Iran

[5] Univ Pavia, Dept Drug Sci, Via Taramelli 12, I-27100 Pavia, Italy

[6] Tours Univ, Fac Dent, Bioengn Biomodulat & Imaging Orofacial Sphere, 2BIOS, Tours, France

[7] Tours Univ, iBrain, UMR 1253, Tours, France

[8] Kermanshah Univ Med Sci, USERN Off, Kermanshah, Iran

[9] Inst Nanotechnol & Correlat Microscopy eV INAM, Forchheim, Germany

[10] Univ Nebraska, Mech & Mat Engn, Lincoln, NE USA

[11] Ardabil Univ Med Sci, Sch Dent, Dept Esthet & Restorat Dent, Ardebil, Iran

[12] Univ Tehran, Fac Engn, Dept Chem Engn, Tehran, Iran

[13] Dublin City Univ, Sch Mech & Mfg Engn, Dublin D09 Y074, Ireland

[14] Dublin City Univ, Ctr Med Engn Res, Sch Mech & Mfg Engn, Dublin D09 Y074, Ireland

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2024年 / 272卷

关键词：

Scaffold; Polycaprolactone; Chitosan; Tissue engineering; Organ; Biomaterial; DRUG-DELIVERY SYSTEMS; IN-VITRO EVALUATION; GALACTOSYLATED CHITOSAN; NANOFIBROUS SCAFFOLDS; EPSILON-CAPROLACTONE; CATIONIC NANOPARTICLES; NANOCOMPOSITE SCAFFOLD; GASTROINTESTINAL-TRACT; POTENTIAL SCAFFOLD; CONTROLLED-RELEASE;

D O I：

10.1016/j.ijbiomac.2024.132941

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Research in creating 3D structures mirroring the extracellular matrix (ECM) with accurate environmental cues holds paramount significance in biological applications.Biomaterials that replicate ECM properties-mechanical, physicochemical, and biological-emerge as pivotal tools in mimicking ECM behavior.Incorporating synthetic and natural biomaterials is widely used to produce scaffolds suitable for the intended organs.Polycaprolactone (PCL), a synthetic biomaterial, boasts commendable mechanical properties, albeit with relatively modest biological attributes due to its hydrophobic nature.Chitosan (CTS) exhibits strong biological traits but lacks mechanical resilience for complex tissue regeneration.Notably, both PCL and CTS have demonstrated their application in tissue engineering for diverse types of tissues.Their combination across varying PCL:CTS ratios has increased the likelihood of fabricating scaffolds to address defects in sturdy and pliable tissues.This comprehensive analysis aspires to accentuate their distinct attributes within tissue engineering across different organs. The central focus resides in the role of PCL:CTS-based scaffolds, elucidating their contribution to the evolution of advanced functional 3D frameworks tailored for tissue engineering across diverse organs.Moreover, this discourse delves into the considerations pertinent to each organ.

引用

页数：26

共 226 条

[1] Kidney transplantation as primary therapy for end-stage renal disease:: A National Kidney Foundation/Kidney Disease Outcomes Quality Initiative (NKF/KDOQI™) conference [J].