Evaluating the efficacy of ubiquinol in heart failure patients: a systematic review and meta-analysis

被引：0

作者：

Qazi, Shurjeel Uddin ^{[1
]}

Bin Naeem, Muhammad Ahrar ^{[2
]}

Umar, Muhammad ^{[2
]}

Zahid, Muhammad Jawad ^{[3
]}

Changez, Mah I. Kan ^{[4
]}

Iqbal, Laraib ^{[5
]}

Sherwani, Ismail Abdur Rahman Khan ^{[6
]}

Mehmood, Hassan ^{[2
]}

Abbasi, Abeera Farooq ^{[1
]}

Zahid, Amna ^{[7
]}

Perswani, Prinka ^{[8
]}

Mattumpuram, Jishanth ^{[9
]}

机构：

[1] Dow Univ Hlth Sci, Dept Med, Karachi 74200, Pakistan

[2] Allama Iqbal Med Coll, Dept Med, Lahore 79180, Pakistan

[3] Hayatabad Med Complex, Dept Surg, Peshawar 25124, Pakistan

[4] Quetta Inst Med Sci, Dept Med, Balochistan 87300, Pakistan

[5] Karachi Med & Dent Coll, Dept Med, Karachi 74600, Pakistan

[6] East & North Hertfordshire NHS Trust, Dept Med, Stevenage SG1 4AB, England

[7] Ziauddin Med Hosp, Dept Surg, Karachi 74700, Pakistan

[8] Univ Calif Riverside, Sch Med, Dept Internal Med, Riverside, CA 92521 USA

[9] Univ Louisville, Sch Med, Dept Med, Div Cardiol, Louisville, KY 40202 USA

来源：

FUTURE CARDIOLOGY | 2024年 / 20卷 / 04期

关键词：

cardiovascular disorders; coenzyme Q10; CoQ-10; heart failure; ubiquinol; COENZYME Q(10); DIASTOLIC FUNCTION;

D O I：

10.1080/14796678.2024.2352308

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim: We aim to analyze past literature to evaluate the efficacy of coenzyme Q10 (CoQ-10) in the population with heart failure (HF). Methods: A systematic literature search was conducted through MEDLINE (via PubMed) and Cochrane Library. The outcomes analyzed were a reduction in HF-related mortality, an improvement in exercise capacity, and the left ventricular ejection fraction (LVEF). Results: Among 16 studies, CoQ-10 significantly reduced HF-related mortality by 40% and improved exercise capacity in patients with HF, but demonstrated no significant difference in LVEF however, the potential of its efficacy on LVEF could not be ruled out. Conclusion: CoQ-10 significantly enhances exercise capacity and reduces HF-related mortality; however, its impact on patients with reduced LVEF requires further investigation.

引用

页码：221 / 228

页数：8

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