Cholesterol-ferroptosis nexus: Unveiling novel cancer therapeutic avenues

被引：8

作者：

Lee, Jaewang ^{[1
,2
]}

Roh, Jong-Lyel ^{[1
,2
]}

机构：

[1] CHA Univ, CHA Bundang Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, Seongnam 13496, Gyeonggi Do, South Korea

[2] CHA Univ, Gen Grad Sch, Dept Biomed Sci, Pochon, South Korea

来源：

CANCER LETTERS | 2024年 / 597卷

基金：

新加坡国家研究基金会;

关键词：

Cholesterol; Biosynthesis; Ferroptosis; Lipid peroxidation; Cancer; FATTY-ACID OXIDATION; LIPID-METABOLISM; MEVALONATE PATHWAY; SQUALENE SYNTHASE; REDOX BIOLOGY; CELLS; DEATH; PEROXIDATION; PROTEOLYSIS; TRAFFICKING;

D O I：

10.1016/j.canlet.2024.217046

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ferroptosis, a novel form of regulated cell death characterized by iron-mediated lipid peroxidation, holds immense potential in cancer therapeutics due to its role in tumor progression and resistance. This review predominantly explores the intricate relationship between ferroptosis and cholesterol metabolism pathways, mainly focusing on the cholesterol biosynthesis pathway. This review highlights the therapeutic implications of targeting cholesterol metabolism pathways for cancer treatment by delving into the mechanisms underlying ferroptosis regulation. Strategies such as inhibiting HMG-CoA reductase and suppressing squalene synthesis offer promising avenues for inducing ferroptosis in cancer cells. Moreover, insights into targeting the 7-dehydrocholesterol pathway provide novel perspectives on modulating ferroptosis susceptibility and managing ferroptosisassociated diseases. Understanding the interplay between ferroptosis and cholesterol metabolism pathways underscores the potential of lipid metabolism modulation as an innovative therapeutic approach in cancer treatment.

引用

页数：9

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