Defining myeloid-derived suppressor cells

被引：15

作者：

Akkari, Leila ^{[1
]}

Amit, Ido ^{[2
]}

Bronte, Vincenzo ^{[3
]}

Fridlender, Zvi G. ^{[4
,5
]}

Gabrilovich, Dmitry I. ^{[6
]}

Ginhoux, Florent ^{[7
,8
]}

Hedrick, Catherine C. ^{[9
,10
,11
]}

Ostrand-Rosenberg, Suzanne ^{[12
,13
]}

机构：

[1] Netherlands Canc Inst, Oncode Inst, Div Tumour Biol & Immunol, Amsterdam, Netherlands

[2] Weizmann Inst Sci, Dept Syst Immunol, Rehovot, Israel

[3] Inst Oncol Veneto IOV IRCCS, Padua, Italy

[4] Hadassah Hebrew Univ, Inst Pulm Med, Med Ctr, Jerusalem, Israel

[5] Hebrew Univ Jerusalem, Fac Med, Jerusalem, Israel

[6] AstraZeneca, ICC, Early Oncol, Gaithersburg, MD 20878 USA

[7] Gustave Roussy Canc Campus, Villejuif, France

[8] Paris Saclay Univ, Paris, France

[9] Augusta Univ, Immunol Ctr Georgia, Augusta, GA 30912 USA

[10] Augusta Univ, Georgia Canc Ctr, Augusta, GA 30912 USA

[11] Augusta Univ, Med Coll Georgia, Dept Med, Augusta, GA 30912 USA

[12] Univ Utah, Dept Pathol, Salt Lake City, UT 84112 USA

[13] Univ Utah, Huntsman Canc Inst, Salt Lake City, UT 84112 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2024年 / 24卷 / 12期

关键词：

TREM2;

D O I：

10.1038/s41577-024-01062-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Myeloid-derived suppressor cells (MDSCs) are cells of neutrophil and monocyte lineages with potent immunosuppressive activity. Numerous studies in mice and humans have identified important roles for MDSCs in suppressing the antitumour response and determining the efficacy of cancer immunotherapies. However, there is still much controversy regarding their identity, ontogeny and functions that must be resolved to fulfill their therapeutic potential. In this Viewpoint, Nature Reviews Immunology invites eight experts in the field to share their thoughts on the key questions and challenges in MDSC research. In this Viewpoint, Nature Reviews Immunology invites eight experts in the field to share their thoughts on the key questions and challenges in MDSC research.

引用

页码：850 / 857

页数：8

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