Targeting SRD5A1 and MMP-2/NLRP3/TGF-β1 axis alleviates the amlodipine-induced gingival hyperplasia in rats: Emerging role of saw palmetto and folic acid

被引：0

作者：

El Tabaa, Manar Mohammed ^{[1
]}

Aboud, Mahmoud Moustafa ^{[2
]}

Anis, Anis ^{[3
]}

Rashad, Eman ^{[4
]}

Sokar, Samia Salem ^{[5
]}

机构：

[1] Univ Sadat City, Environm Studies Res Inst ESRI, Pharmacol & Environm Toxicol, Sadat City 32897, Menoufia, Egypt

[2] Univ Sadat City, Environm Studies & Res Inst ESRI, Dent Sci, Sadat City 32897, Menoufia, Egypt

[3] Univ Sadat City, Fac Vet Med, Pathol, Sadat City 32897, Menoufia, Egypt

[4] Cairo Univ, Fac Vet Med, Cytol & Histol Dept, Cairo, Egypt

[5] Tanta Univ, Fac Pharm, Pharmacol & Toxicol, Tanta, Egypt

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2024年 / 189卷

关键词：

Amlodipine; Gingival hyperplasia; MMP-2/NLRP3/TGF-beta; 1; axis; Saw palmetto; Folic acid; GLYCOGEN-SYNTHASE KINASE-3-BETA; 5; ALPHA-REDUCTASE; SERENOA-REPENS; OXIDATIVE STRESS; TNF-ALPHA; KAPPA-B; OVERGROWTH; INHIBITION; PROSTATE; TISSUE;

D O I：

10.1016/j.fct.2024.114731

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Saw palmetto (SAW), the herbal drug used to treat prostatic hyperplasia, exerts its antiproliferative effects by blocking steroid 5 alpha-reductase (SRD5A1) activity, that has also been involved in gingival hyperplasia (GH) pathogenesis. Concurrently, folic acid (FA) could reduce GH prevalence via its antioxidant and anti-inflammatory effects. Thus, this study tended to assess the potential therapeutic efficacy of SAW, alone and along with FA, against amlodipine-induced gingival inflammation and overgrowth in rats. Rats were grouped into (CONT, AIGH, SAW, SAW-treated, FA-treated, and SAW + FA-treated). SAW and FA were administered once daily for 4 weeks. Gingival SRD5A1, CTGF, GSK-3 beta, and NLRP3 expressions, as well as T, DHT, MDA, TAC, ET-1, and MMP2 levels were determined. In addition, histopathological and immunohistochemical analyses of TNF-alpha, IL-6, TGF-beta 1, and alpha-SMA were documented. Results declared that SAW and FA administration markedly ameliorated amlodipineassociated GH and may be presenting a novel therapeutic avenue in the future.

引用

页数：17

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